Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, Massachusetts, USA.
Int J Psychophysiol. 2011 Jan;79(1):55-63. doi: 10.1016/j.ijpsycho.2010.08.004. Epub 2010 Aug 14.
Phase locking in the gamma-band range has been shown to be diminished in patients with schizophrenia. Moreover, there have been reports of positive correlations between phase locking in the gamma-band range and positive symptoms, especially hallucinations. The aim of the present study was to use a new methodological approach in order to investigate gamma-band phase synchronization between the left and right auditory cortex in patients with schizophrenia and its relationship to auditory hallucinations. Subjects were 18 patients with chronic schizophrenia (SZ) and 16 healthy control (HC) subjects. Auditory hallucination symptom scores were obtained using the Scale for the Assessment of Positive Symptoms. Stimuli were 40-Hz binaural click trains. The generators of the 40Hz-ASSR were localized using eLORETA and based on the computed intracranial signals lagged interhemispheric phase locking between primary and secondary auditory cortices was analyzed. Current source density of the 40 ASSR response was significantly diminished in SZ in comparison to HC in the right superior and middle temporal gyrus (p<0.05). Interhemispheric phase locking was reduced in SZ in comparison to HC for the primary auditory cortices (p<0.05) but not in the secondary auditory cortices. A significant positive correlation was found between auditory hallucination symptom scores and phase synchronization between the primary auditory cortices (p<0.05, corrected for multiple testing) but not for the secondary auditory cortices. These results suggest that long-range synchrony of gamma oscillations is disturbed in schizophrenia and that this deficit is related to clinical symptoms such as auditory hallucinations.
在精神分裂症患者中,γ 波段的相位锁定已被证明减弱。此外,已有研究报道 γ 波段的相位锁定与阳性症状,尤其是幻觉之间存在正相关。本研究旨在采用一种新的方法学方法,来研究精神分裂症患者左、右听觉皮层之间的 γ 波段相位同步及其与听觉幻觉的关系。研究对象为 18 名慢性精神分裂症患者(SZ)和 16 名健康对照者(HC)。采用阳性症状评定量表(Scale for the Assessment of Positive Symptoms)来获取听觉幻觉症状评分。刺激为 40Hz 双耳 click 音串。采用 eLORETA 定位 40Hz-ASSR 的发生器,并基于计算得出的颅内信号,分析初级和次级听觉皮层之间的滞后半球间相位锁定。与 HC 相比,SZ 右侧上颞回和中颞回的 40 赫兹 ASSR 反应的电流源密度显著降低(p<0.05)。与 HC 相比,SZ 的初级听觉皮层之间的相位锁定减少(p<0.05),但在次级听觉皮层中没有减少。听觉幻觉症状评分与初级听觉皮层之间的相位同步呈显著正相关(p<0.05,经多重检验校正),但与次级听觉皮层无关。这些结果表明,精神分裂症患者的γ 波段同步长程同步受到干扰,这种缺陷与听觉幻觉等临床症状有关。