Department of Gynecologic Surgery.
Department of Biostatistics.
Ann Oncol. 2011 Mar;22(3):631-635. doi: 10.1093/annonc/mdq414. Epub 2010 Aug 16.
The aim of this study was to describe how recurrences were diagnosed in the largest series of patients treated for an advanced-stage serous borderline ovarian tumour.
From 1973 to 2006, 45 patients with a serous borderline tumour and peritoneal implants relapsed among 162 patients with a follow-up exceeding 1 year. Data concerning recurrences and the mode of diagnosis were reviewed.
The median follow-up interval was 8.2 years (range 19-286 months). The mode of diagnosis of recurrences was imaging (n = 19), clinical symptoms (n = 8), cancer antigen (CA) 125 elevation (n = 7), secondary surgery (n = 5) and unknown (n = 6). The median time to recurrence was 31 months (range 4-242 month). The type of recurrence was invasive low-grade serous carcinoma in 14 patients. Five patients died of recurrent tumour. Among the 39 patients with a known mode of diagnosis of recurrence, the most frequent diagnostic method for invasive recurrences was blood CA 125 elevation (6 of 13) and the majority of noninvasive recurrences were diagnosed by imaging (16 of 23).
This study demonstrates that ultrasound is the most relevant follow-up procedure in this context. Nevertheless, the blood CA 125 test is of particular interest for detecting invasive recurrent disease, which is the most crucial event.
本研究旨在描述在最大系列接受高级别浆液性交界性卵巢肿瘤治疗的患者中，如何诊断复发。
1973 年至 2006 年，在随访时间超过 1 年的 162 例患者中，有 45 例浆液性交界性肿瘤和腹膜种植物患者复发。回顾了复发和诊断方式的数据。
中位随访间隔为 8.2 年（范围 19-286 个月）。诊断复发的方式为影像学（n = 19）、临床症状（n = 8）、癌抗原 125 升高（n = 7）、二次手术（n = 5）和未知（n = 6）。复发的中位时间为 31 个月（范围 4-242 个月）。14 例患者发生侵袭性低级别浆液性癌复发。5 例患者死于复发性肿瘤。在 39 例已知复发诊断方式的患者中，诊断侵袭性复发最常见的方法是血液 CA 125 升高（13 例中的 6 例），大多数非侵袭性复发通过影像学诊断（23 例中的 16 例）。
本研究表明，在这种情况下，超声是最相关的随访程序。然而，CA 125 血液检测对于检测侵袭性复发性疾病特别有意义，因为这是最关键的事件。
