TMPHPG：一种用于铁、镓-68和铟-111肝胆清除的EHPG亲脂性衍生物。
TMPHPG: a lipophilic derivative of EHPG for iron, gallium-68 and indium-111 hepatobiliary clearance.
作者信息
Madsen S L, Bannochie C J, Welch M J, Mathias C J, Martell A E
机构信息
Edward Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, MO 63110.
出版信息
Int J Rad Appl Instrum B. 1991;18(3):289-94. doi: 10.1016/0883-2897(91)90124-4.
TMPHPG (N,N'-trimethylenebis[2-(2-hydroxy-3,5-dimethylphenyl)glycine]) is a derivative of the ligand EHPG (ethylenebis[2-(o-hydroxyphenyl)glycine]) but is more lipophilic and had been synthesized to increase hepatobiliary clearance. 59Fe(III), 68Ga(III) and 111In(III) complexes of this ligand have been investigated as potential imaging agents for MRI, PET and SPECT, respectively. Metal-dependent differences in blood and liver clearance in mature rats have been evaluated.
TMPHPG（N，N'-亚甲基双[2-（2-羟基-3，5-二甲基苯基）甘氨酸]）是配体EHPG（亚乙基双[2-（邻羟基苯基）甘氨酸]）的衍生物，但亲脂性更强，已被合成用于提高肝胆清除率。该配体的59Fe（III）、68Ga（III）和111In（III）配合物已分别作为MRI、PET和SPECT的潜在成像剂进行了研究。已评估了成熟大鼠体内血液和肝脏清除率的金属依赖性差异。
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