Madsen S L, Bannochie C J, Welch M J, Mathias C J, Martell A E
Edward Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, MO 63110.
Int J Rad Appl Instrum B. 1991;18(3):289-94. doi: 10.1016/0883-2897(91)90124-4.
TMPHPG (N,N'-trimethylenebis[2-(2-hydroxy-3,5-dimethylphenyl)glycine]) is a derivative of the ligand EHPG (ethylenebis[2-(o-hydroxyphenyl)glycine]) but is more lipophilic and had been synthesized to increase hepatobiliary clearance. 59Fe(III), 68Ga(III) and 111In(III) complexes of this ligand have been investigated as potential imaging agents for MRI, PET and SPECT, respectively. Metal-dependent differences in blood and liver clearance in mature rats have been evaluated.
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