• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Potential radiopharmaceuticals for the diagnosis of biliary atresia and neonatal hepatitis: EHPG and HBED chelates of 67Ga and 111In.

作者信息

Hunt F C

机构信息

Australian Nuclear Science and Technology Organisation, Lucas Heights Research Laboratories, Menai, NSW.

出版信息

Int J Rad Appl Instrum B. 1988;15(6):659-64. doi: 10.1016/0883-2897(88)90058-x.

DOI:10.1016/0883-2897(88)90058-x
PMID:3150845
Abstract

Radiopharmaceuticals suitable for use in cases where delayed excretion of hepatobiliary tracer can occur, were formulated from indium-111 and gallium-67 and the chelating agents N,N'-ethylene-bis-[o-hydroxy-phenylglycine], (EHPG) and N,N'-bis-[2-hydroxybenzyl] ethylenediamine-N,N'-diacetic acid, (HBED). The hepatobiliary excretion of these 67Ga and 111In chelates was optimised by using chelators which had substituents in the phenolic ring; halogen substituents imparted the most favourable characteristics.

摘要

相似文献

1
Potential radiopharmaceuticals for the diagnosis of biliary atresia and neonatal hepatitis: EHPG and HBED chelates of 67Ga and 111In.
Int J Rad Appl Instrum B. 1988;15(6):659-64. doi: 10.1016/0883-2897(88)90058-x.
2
Phenolic aminocarboxylic acids as gallium-binding radiopharmaceuticals.
Nuklearmedizin. 1984 Jun;23(3):123-5.
3
Comparison of Fe-HBED and Fe-EHPG as hepatobiliary MR contrast agents.
J Magn Reson Imaging. 1991 May-Jun;1(3):357-62. doi: 10.1002/jmri.1880010314.
4
Phenolic aminocarboxylate chelates of 99mTc as hepatobiliary agents.作为肝胆显像剂的99mTc酚氨基羧酸盐螯合物。
Int J Rad Appl Instrum B. 1986;13(3):289-93. doi: 10.1016/0883-2897(86)90111-x.
5
Targeting radiopharmaceuticals: comparative biodistribution studies of gallium and indium complexes of multidentate ligands.
Int J Rad Appl Instrum B. 1988;15(1):69-81. doi: 10.1016/0883-2897(88)90163-8.
6
UV and fluorescence spectral changes induced by neodymium binding of N,N'-ethylenebis[2-(o-hydroxyphenolic)glycine] and N,N'-di(2-hydroxybenzyl)ethylenediamine-N,N' diacetic acid.钕与N,N'-亚乙基双[2-(邻羟基苯基)甘氨酸]及N,N'-二(2-羟基苄基)乙二胺-N,N'-二乙酸结合所诱导的紫外和荧光光谱变化
Spectrochim Acta A Mol Biomol Spectrosc. 2006 Nov;65(3-4):946-9. doi: 10.1016/j.saa.2005.04.058. Epub 2006 May 8.
7
Development and evaluation of the improved iron chelating agents EHPG, HBED and their dimethyl esters.改良铁螯合剂EHPG、HBED及其二甲酯的研发与评估。
Haematologia (Budap). 1984;17(1):25-33.
8
Phenolic ethylenediamine derivatives: a study of orally effective iron chelators.酚类乙二胺衍生物：口服有效的铁螯合剂的研究
J Lab Clin Med. 1984 Mar;103(3):337-46.
9
A bifunctional HBED-derivative for labeling of antibodies with 67Ga, 111In and 59Fe. Comparative biodistribution with 111In-DPTA and 131I-labeled antibodies in mice bearing antibody internalizing and non-internalizing tumors.一种用于用67Ga、111In和59Fe标记抗体的双功能HBED衍生物。与111In-DPTA和131I标记的抗体在荷有抗体内化和非内化肿瘤的小鼠中的比较生物分布。
Int J Rad Appl Instrum B. 1992 Nov;19(8):809-24. doi: 10.1016/0883-2897(92)90167-w.
10
Chelator-induced enhancement of 67Ga tumour imaging: comparison of desferrioxamine with N,N'-ethylene-bis[2-hydroxy-5-carboxyphenylglycine].螯合剂诱导的67Ga肿瘤显像增强：去铁胺与N,N'-亚乙基双[2-羟基-5-羧基苯基甘氨酸]的比较
Int J Rad Appl Instrum B. 1988;15(6):651-7. doi: 10.1016/0883-2897(88)90057-8.

引用本文的文献

1
Thwarting Isomerization through Rigidity: A Promising HBED Derivative for the Chelation of Gallium-68.通过刚性阻止异构化：一种用于螯合镓-68的有前景的HBED衍生物。
Inorg Chem. 2025 Sep 22;64(37):18673-18686. doi: 10.1021/acs.inorgchem.5c00930. Epub 2025 Jul 17.