Department of Psychiatry & MRC/Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK.
Psychopharmacology (Berl). 2010 Dec;212(4):597-601. doi: 10.1007/s00213-010-1981-x. Epub 2010 Aug 17.
Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair.
The aim of this study is to examine whether modafinil improves motor inhibitory control, and other cognitive functions, in trichotillomania.
Eighteen subjects with trichotillomania (mean age 33.4 ± 12.8 years; 78% female) received a single dose of modafinil (200 mg) and placebo in a crossover double-blind design. Neurocognitive performance was assessed using the stop-signal, pattern recognition, rapid visual information processing and Tower of London tasks.
No effects of modafinil on cognition approached statistical significance on the test measures examined (all p > 0.10).
These results suggest that modafinil may not be useful for targeting impulse dyscontrol in trichotillomania. However, it remains possible that relatively small effects of modafinil on cognition could exert larger downstream effects on overt behaviour. Further trials using modafinil and other pro-cognitive agents are warranted.
患有拔毛癖的个体经常报告说，他们很难抵抗拔毛发的冲动和驱动力。
本研究旨在检验莫达非尼是否能改善拔毛癖患者的运动抑制控制和其他认知功能。
18 名患有拔毛癖的患者（平均年龄 33.4 ± 12.8 岁；78%为女性）接受了莫达非尼（200mg）和安慰剂的交叉双盲设计的单次剂量。使用停止信号、模式识别、快速视觉信息处理和伦敦塔任务评估神经认知表现。
在测试的测量中，莫达非尼对认知的影响均未达到统计学意义（所有 p>0.10）。
这些结果表明，莫达非尼可能对治疗拔毛癖的冲动控制障碍没有作用。然而，莫达非尼对认知的相对较小的影响可能会对明显的行为产生更大的下游影响。使用莫达非尼和其他促进认知的药物进行进一步的试验是有必要的。
