Nenoff Pietro, Herrmann Antonia, Gerlach Christina, Herrmann Jürgen, Simon Jan Christoph
Laboratorium für Medizinische Mikrobiologie, Mölbis, Germany.
Wien Med Wochenschr. 2010 Dec;160(21-22):578-85. doi: 10.1007/s10354-010-0806-1. Epub 2010 Aug 16.
During the last years an increasing number of patients suffering from therapy refractory chronic wounds which are frequently infected by multi-resistant bacteria - e.g. methicillin-resistant Staphylococcus aureus - have led to an increasing interest in the treatment using larvae or maggots of the blow fly species Lucilia sericata. Maggots are responsible for necrectomy and they have antimicrobial activity in particular against grampositive bacteria like a disinfectant of the wound. It is concluded that maggots debridement therapy (MDT) using larvae of the species Lucilia sericata in non-healing chronic ulcers of the lower legs successfully leads to cleaning, debridement, reduced bacterial load, and improved wound granulation. A review is given on the clinical use of maggots, their mechanism of action and clinical efficacy for wound healing.
在过去几年中,越来越多患有治疗难治性慢性伤口的患者,这些伤口经常被多重耐药菌感染,例如耐甲氧西林金黄色葡萄球菌,这使得人们对使用丝光绿蝇幼虫或蛆虫进行治疗的兴趣日益增加。蛆虫负责坏死组织清除,它们具有抗菌活性,特别是对革兰氏阳性菌,就像伤口消毒剂一样。得出的结论是,在小腿慢性不愈合溃疡中使用丝光绿蝇幼虫进行蛆虫清创疗法(MDT)成功地实现了清洁、清创、降低细菌载量以及改善伤口肉芽形成。本文综述了蛆虫的临床应用、作用机制及其对伤口愈合的临床疗效。