Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
J Gen Intern Med. 2010 Dec;25(12):1293-9. doi: 10.1007/s11606-010-1473-z. Epub 2010 Aug 17.
Coronary artery disease (CAD) is highly prevalent in nursing home residents and is associated with a substantial clinical and economic burden. Statins reduce mortality and hospitalization rates in older patients with CAD.
To assess rates and predictors of statin use among high-risk patients with symptomatic coronary artery disease (CAD) admitted to nursing homes after acute cardiac hospitalization.
Cohort study.
Medicare beneficiaries enrolled in either a state-run drug assistance program or Medicaid in nursing homes in New Jersey from 1994 through 2005.
Statin utilization within 60 days of nursing home admission was determined for patients recently hospitalized with symptomatic CAD in whom statins are indicated consisting of those with: acute coronary syndrome (ACS) without revascularization, ACS with revascularization and congestive heart failure (CHF) with revascularization. Predictors of statin use were evaluated with multivariate logistic regression models.
While statin use over the 11-year period increased from 1.2% to 31.8%, overall utilization was very low. Predictors of greater statin use included prior cardiac hospitalization [odds ratio (OR) 1.32, 95% confidence interval (95% CI) 1.13 to 1.57], prior statin use (OR 6.92, 95% CI 5.86 to 8.82) and receipt of a concurrent cardiac medication (range of odds ratios, 2.36-3.40). Older patients admitted for ACS with or without revascularization were less likely to receive a statin. Patients who had received anti-platelets or angiotensin-modifying agents prior to their hospitalization were less likely to receive statins after discharge. Renal disease, prior stroke, diabetes, hypertension and hyperlipidemia did not influence statin utilization. Predictors of treatment did not change when the cohort was dichotomized according to length of stay.
Patients are infrequently treated with statins when discharged to nursing homes following hospitalization for a symptomatic cardiovascular event. Barriers to statin treatment in this setting require closer examination.
冠心病(CAD)在养老院居民中高发,与大量临床和经济负担相关。他汀类药物可降低老年 CAD 患者的死亡率和住院率。
评估急性心脏住院后入住养老院的有症状冠状动脉疾病(CAD)高危患者使用他汀类药物的比例和预测因素。
队列研究。
1994 年至 2005 年间,新泽西州养老院中参加州立药物援助计划或医疗补助计划的 Medicare 受益人。
最近因有症状 CAD 住院且需要他汀类药物治疗(包括无血运重建的急性冠状动脉综合征(ACS)、有血运重建的 ACS 和有血运重建的充血性心力衰竭(CHF))的患者,在入住养老院后 60 天内使用他汀类药物的情况。使用多变量逻辑回归模型评估他汀类药物使用的预测因素。
虽然他汀类药物的使用在 11 年期间从 1.2%增加到 31.8%,但总体使用率仍然非常低。他汀类药物使用更多的预测因素包括既往心脏住院治疗(比值比 [OR] 1.32,95%置信区间 [95%CI] 1.13 至 1.57)、既往使用他汀类药物(OR 6.92,95%CI 5.86 至 8.82)和接受同时使用心脏药物(比值比范围,2.36-3.40)。因 ACS 接受或未接受血运重建而入院的老年患者更不可能接受他汀类药物治疗。在住院前接受抗血小板或血管紧张素调节剂治疗的患者在出院后更不可能接受他汀类药物治疗。肾脏疾病、既往中风、糖尿病、高血压和高脂血症并不影响他汀类药物的使用。当根据住院时间将队列分为两组时,治疗的预测因素没有改变。
在因有症状心血管事件住院后入住养老院的患者中,他汀类药物的使用率较低。需要更仔细地检查这种情况下他汀类药物治疗的障碍。