CPS Research, Glasgow, UK.
Int Clin Psychopharmacol. 2010 Sep;25(5):288-96. doi: 10.1097/yic.0b013e328339fbcf.
This systematic review examines the economic and human costs of depression and the potential savings associated with improvement in patient adherence to treatment with antidepressants through the use of enhanced-care programs. A MEDLINE search was conducted for papers published on the health economics and costs of depression and compliance, adherence, and persistence. Compliance data collected through the online antidepressant compliance support website iCAN (www.ican.co.uk) were compared with data for patients with depression from the IMS Disease Analyzer UK database. Depression frequently causes unemployment, absenteeism, and presenteeism, which results in significantly reduced productivity. Indirect costs of depression accounted for more than $50 billion, whereas direct costs resulted in expenditure of $26 billion, in the US in 2000. Improving patients' compliance with their antidepressant medication results in improved outcomes and prolongs remission from depression, increasing work productivity, and thus reducing overall costs. The implementation of remote enhanced-care programs may improve compliance and reduce overall costs. Novel methods for delivering enhanced-care programs to assist in maintaining compliance have the potential to further reduce costs and should be a focus of future research. In conclusion, depression is a common disorder with a high economic impact. Enhanced-care programs may lower costs associated with depression and improve patients' lives.
本系统评价研究了抑郁症的经济和人力成本，以及通过使用强化护理方案提高患者对抗抑郁药治疗的依从性，从而降低成本的潜力。对有关抑郁症的健康经济学和成本以及依从性、遵医嘱用药和持续用药的研究进行了 MEDLINE 检索。将通过在线抗抑郁药依从性支持网站 iCAN（www.ican.co.uk）收集的依从性数据与 IMS Disease Analyzer UK 数据库中抑郁症患者的数据进行了比较。抑郁症常常导致失业、旷工和出勤但工作效率低下，从而导致生产力显著降低。2000 年，在美国，抑郁症的间接成本超过 500 亿美元，而直接成本则达到 260 亿美元。提高患者对抗抑郁药物的依从性可改善治疗结果并延长抑郁缓解期，提高工作效率，从而降低总体成本。实施远程强化护理方案可能会提高依从性并降低总体成本。提供强化护理方案的新方法有望进一步降低成本，应成为未来研究的重点。总之，抑郁症是一种常见疾病，具有很高的经济影响。强化护理方案可能会降低与抑郁症相关的成本并改善患者的生活。
