Silvestro Orlando, Lund-Jacobsen Trine, Ferraù Francesco, Blanca Elena Sofia, Catalano Antonino, Sparacino Giorgio, Schwarz Peter, Cannavò Salvatore, Martino Gabriella
Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Department of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
J Endocrinol Invest. 2025 Mar;48(3):527-546. doi: 10.1007/s40618-024-02483-3. Epub 2024 Nov 7.
scientific literature highlights risk factors linked to the onset of psychopathology in different medical pathological contexts. Acromegaly is a rare condition, particularly noteworthy due to the associated clinical psychological features. This research aimed at understanding the main psychopathological outcomes related to acromegaly, with particular emphasis to anxiety and depression.
In January 2024, in line with PRISMA guidelines, a systematic search based on PubMed, Scopus, Web of Science and PsycInfo was conducted to detect studies considering anxiety, depression and alexithymia in patients suffering from acromegaly. The Keywords used for the search phase were "Acromegaly" AND "Depression" OR "Anxiety" OR "Alexithymia".
Fifty-five studies were eligible. Anxiety and depression were significantly present in patients with acromegaly, with prevalence rates variable based on disease status and psycho-diagnostic instruments. None of the included studies reported alexithymia in patients with acromegaly. No significant difference was found regarding anxiety and depressive symptoms in patients with acromegaly in comparison with patients suffering from different pituitary diseases and chronic conditions. Anxiety and depression were associated with lower perceived HR-QoL, presence of comorbidity, joint issues, delayed diagnosis, disease duration and body image concerns.
Anxiety and depression may be encountered in patients with acromegaly, impacting HR-QoL and the course of the disease. This systematic review suggests that a deeper evaluation of clinical psychological features in patients suffering from acromegaly is needed. Particularly, the early detection of clinical psychological symptoms may lead to multi-integrate interventions promoting individuals' well-being and a better HR-QoL.
科学文献强调了在不同医学病理背景下与精神病理学发作相关的风险因素。肢端肥大症是一种罕见疾病，因其相关的临床心理特征而尤为值得关注。本研究旨在了解与肢端肥大症相关的主要精神病理学结果，特别关注焦虑和抑郁。
2024年1月，按照PRISMA指南，在PubMed、Scopus、科学网和PsycInfo上进行了系统检索，以查找有关肢端肥大症患者焦虑、抑郁和述情障碍的研究。检索阶段使用的关键词为“肢端肥大症”与“抑郁”或“焦虑”或“述情障碍”。
55项研究符合条件。肢端肥大症患者中焦虑和抑郁显著存在，患病率因疾病状态和心理诊断工具而异。纳入的研究均未报告肢端肥大症患者存在述情障碍。与患有不同垂体疾病和慢性病的患者相比，肢端肥大症患者的焦虑和抑郁症状无显著差异。焦虑和抑郁与较低的健康相关生活质量感知、合并症的存在、关节问题、诊断延迟、疾病持续时间和身体形象问题有关。
肢端肥大症患者可能会出现焦虑和抑郁，影响健康相关生活质量和疾病进程。本系统评价表明，需要对肢端肥大症患者的临床心理特征进行更深入的评估。特别是，早期发现临床心理症状可能会导致多方面综合干预，促进个体的幸福感和更好的健康相关生活质量。
