Ikeda Kenichiro, Kimura Y
Department of Surgery, Clinical Oncology Center, Iwate Medical University, Morioka, Japan.
Kyobu Geka. 2008 Jul;61(8 Suppl):726-30.
High incidence of malnutrition is found in esophageal cancer patients. It is well known that to maintain good nutritional preoperative condition is very important to prevent postoperative morbidity and mortality. Hence, preoperative oral or nasogastric feeding is recommended when the patient is malnourished, at a total dose of 30 kcal/kg/day. During postoperative period, enteral nutrition should be primarily performed because of its favorable effects on immune-status and intestinal integrity to avoid septic complications. It is also important to keep circulatory volume sufficient to provide oxygen demand during catabolic phase, which leads earlier recovery from critical illness. Enteral nutrition should be immediately started afterward. An initial dose of 5-10 kcal/kg/day of the enteral nutrition is performed from the 1st or 2nd postoperative day and gradually increased to the full dose at 30 kcal/kg/ day. In cases of not administering scheduled dose of the enteral nutrition, either total or peripheral parenteral nutrition is required complementing total caloric intake. When total parenteral nutrition is used, blood glucose level should be controlled less than 150 mg/dl by pertinently administering insulin or limiting glycemic intake. Immunonutrition is promising nutritional management for critical surgical patients such as those performed esophageal cancer surgery. Continuing immune-enhancing diet at a dose of 750 to 1,000 ml/day for 5 to 7 days before surgery is necessary to bring good postoperative outcome.
食管癌患者中营养不良的发生率很高。众所周知,维持良好的术前营养状况对于预防术后发病率和死亡率非常重要。因此,当患者营养不良时,建议术前经口或鼻胃管喂养,总剂量为30千卡/千克/天。术后期间,应主要进行肠内营养,因为其对免疫状态和肠道完整性有良好影响,可避免感染性并发症。在分解代谢阶段,保持足够的循环血容量以满足氧气需求也很重要,这有助于患者从危重病中更早恢复。之后应立即开始肠内营养。术后第1天或第2天开始肠内营养,初始剂量为5 - 10千卡/千克/天,并逐渐增加至30千卡/千克/天的全剂量。如果未按计划给予肠内营养剂量,则需要通过全胃肠外营养或外周静脉营养补充总热量摄入。使用全胃肠外营养时,应通过适当注射胰岛素或限制血糖摄入将血糖水平控制在150毫克/分升以下。免疫营养对于食管癌手术等重症外科患者来说是一种很有前景的营养管理方法。术前持续5至7天给予剂量为750至1000毫升/天的免疫增强饮食对于取得良好的术后效果很有必要。