Bone Tumour Service, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, UK.
Int J Clin Pract. 2010 Sep;64(10):1444-52. doi: 10.1111/j.1742-1241.2010.02420.x.
Defects in knee articular cartilage (AC) can cause pain and disability and present the clinician with an extremely challenging clinical situation. This article describes the most up-to-date surgical techniques that aim to repair and/or regenerate symptomatic focal defects in AC, which include arthroscopic debridement, microfracture bone marrow stimulation and autologous osteochondral allografting, with an emphasis on autologous chondrocyte implantation. In the future, refinement of tissue-engineering approaches promises to further improve outcome for these patients.
膝关节软骨(AC)缺陷可引起疼痛和功能障碍,并给临床医生带来极具挑战性的临床情况。本文描述了最新的手术技术,旨在修复和/或再生 AC 中的有症状的局灶性缺陷,包括关节镜下清创术、微骨折骨髓刺激和自体骨软骨移植,重点是自体软骨细胞移植。未来,组织工程方法的改进有望进一步改善这些患者的预后。