从细胞到器官：再生医学的现在和未来。
From Cells to Organs: The Present and Future of Regenerative Medicine.
机构信息
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
出版信息
Adv Exp Med Biol. 2022;1376:135-149. doi: 10.1007/5584_2021_657.
Abstract
Regenerative medicine promises a bright future where damaged body parts can be restored, rejuvenated, and replaced. The application of regenerative medicine is interdisciplinary and covers nearly all fields of medical sciences and molecular engineering. This review provides a road map on how regenerative medicine is applied on the levels of cell, tissue, and organ and summarizes the advantages and limitation of human pluripotent stem cells in disease modeling and regenerative application.
摘要
再生医学前景光明，有朝一日，受损的身体部位有望得到修复、恢复活力和替换。再生医学的应用是跨学科的，涵盖了几乎所有医学科学和分子工程领域。本文综述了再生医学在细胞、组织和器官水平上的应用，并总结了人多能干细胞在疾病建模和再生应用中的优势和局限性。
相似文献
1
From Cells to Organs: The Present and Future of Regenerative Medicine.
Adv Exp Med Biol. 2022;1376:135-149. doi: 10.1007/5584_2021_657.
2
Kidney Organoids: A Translational Journey.
Trends Mol Med. 2017 Mar;23(3):246-263. doi: 10.1016/j.molmed.2017.01.001. Epub 2017 Feb 7.
3
Human Pluripotent Stem Cells: Applications and Challenges for Regenerative Medicine and Disease Modeling.
Adv Biochem Eng Biotechnol. 2020;171:189-224. doi: 10.1007/10_2019_117.
4
Application of Organoids in Regenerative Medicine.
Stem Cells. 2023 Dec 14;41(12):1101-1112. doi: 10.1093/stmcls/sxad072.
5
Derivation and application of pluripotent stem cells for regenerative medicine.
Sci China Life Sci. 2016 Jun;59(6):576-83. doi: 10.1007/s11427-016-5066-x. Epub 2016 May 26.
6
The Utility of Human Kidney Organoids in Modeling Kidney Disease.
Semin Nephrol. 2020 Mar;40(2):188-198. doi: 10.1016/j.semnephrol.2020.01.009.
7
Kidney organoids in translational medicine: Disease modeling and regenerative medicine.
Dev Dyn. 2020 Jan;249(1):34-45. doi: 10.1002/dvdy.22. Epub 2019 Mar 26.
8
Emerging trends and new developments in regenerative medicine: a scientometric update (2000 - 2014).
Expert Opin Biol Ther. 2014 Sep;14(9):1295-317. doi: 10.1517/14712598.2014.920813. Epub 2014 Jul 31.
9
[Progress of lung organoids in lung epithelial repair and regenerative medicine].
Zhonghua Jie He He Hu Xi Za Zhi. 2023 Aug 12;46(8):819-824. doi: 10.3760/cma.j.cn112147-20230223-00087.
10
Regenerative medicine for urological tissues: Updated review 2018.
Int J Urol. 2018 Sep;25(9):788-791. doi: 10.1111/iju.13762. Epub 2018 Jul 31.
引用本文的文献
1
Revolutionising health care: Exploring the latest advances in medical sciences.
J Glob Health. 2023 Aug 4;13:03042. doi: 10.7189/jogh.13.03042.
2
Extracellular Matrix-Based and Electrospun Scaffolding Systems for Vaginal Reconstruction.
Bioengineering (Basel). 2023 Jul 1;10(7):790. doi: 10.3390/bioengineering10070790.
3
Development of Matrix Metalloproteinases-Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review.
Tissue Eng Regen Med. 2023 Aug;20(5):661-670. doi: 10.1007/s13770-023-00536-x. Epub 2023 May 9.
4
Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments.
J Funct Biomater. 2023 Jan 20;14(2):58. doi: 10.3390/jfb14020058.
本文引用的文献
1
Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges.
Cell Stem Cell. 2020 Oct 1;27(4):523-531. doi: 10.1016/j.stem.2020.09.014.
2
Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope.
Stem Cells Int. 2020 Jun 30;2020:5690252. doi: 10.1155/2020/5690252. eCollection 2020.
3
Recent Advances in the Treatment of Sickle Cell Disease.
Front Physiol. 2020 May 20;11:435. doi: 10.3389/fphys.2020.00435. eCollection 2020.
4
Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery.
Neurosci Lett. 2020 Jul 13;731:135028. doi: 10.1016/j.neulet.2020.135028. Epub 2020 May 4.
5
Overcoming kidney organoid challenges for regenerative medicine.
NPJ Regen Med. 2020 Apr 30;5:8. doi: 10.1038/s41536-020-0093-4. eCollection 2020.
6
A Liver Model of Infantile-Onset Pompe Disease Using Patient-Specific Induced Pluripotent Stem Cells.
Front Cell Dev Biol. 2019 Nov 29;7:316. doi: 10.3389/fcell.2019.00316. eCollection 2019.
7
iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery.
Front Med (Lausanne). 2019 Nov 15;6:265. doi: 10.3389/fmed.2019.00265. eCollection 2019.
8
De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans.
Nat Biotechnol. 2019 Oct;37(10):1137-1144. doi: 10.1038/s41587-019-0227-7. Epub 2019 Aug 19.
9
Factors affecting mortality during the waiting time for kidney transplantation: A nationwide population-based cohort study using the Korean Network for Organ Sharing (KONOS) database.
PLoS One. 2019 Apr 12;14(4):e0212748. doi: 10.1371/journal.pone.0212748. eCollection 2019.
10
Patient-Derived Induced Pluripotent Stem Cells for Alpha-1 Antitrypsin Deficiency Disease Modeling and Therapeutic Discovery.
Chronic Obstr Pulm Dis. 2018 Sep 15;5(4):258-266. doi: 10.15326/jcopdf.5.4.2017.0179.
Zotero 插件