3-取代β-咔啉类化合物的简便合成 3-取代 9H-吡啶并[3,4-b]吲哚-1(2H)-酮衍生物。
A facile synthesis of 3-substituted 9H-pyrido[3,4-b]indol-1(2H)-one derivatives from 3-substituted beta-carbolines.
机构信息
College of Basic Science, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Molecules. 2010 Aug 17;15(8):5680-91. doi: 10.3390/molecules15085680.
Abstract
A mild and efficient two-step synthesis of 3-substituted beta-carbolinone derivatives from 3-substituted beta-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of beta-carbolin-1-one is proposed. The structures of these compounds were established by IR, 1H-NMR, 13C-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.
摘要
描述了一种从 3-取代的β-咔啉出发，高产率、温和且高效的两步法合成 3-取代的β-咔啉酮衍生物的方法。提出了β-咔啉-1-酮骨架形成的可能反应机理。这些化合物的结构通过红外光谱（IR）、核磁共振氢谱（1H-NMR）、核磁共振碳谱（13C-NMR）、质谱（MS）和元素分析进行了确定，同时通过 X 射线晶体学分析确定了 4-2 和 6-2 的结构。
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