内分泌干扰物与肥胖：对 NHANES 1999-2002 数据中部分持久性有机污染物的检测。
Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 data.
机构信息
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Int J Environ Res Public Health. 2010 Jul;7(7):2988-3005. doi: 10.3390/ijerph7072988. Epub 2010 Jul 23.
Abstract
Recent evidence suggests that endocrine disrupting chemicals (EDCs) may cause perturbations in endogenous hormonal regulation that predispose to weight gain. Using data from NHANES (1999-2002), we investigated the association between body mass index (BMI), waist circumference (WC) and selected persistent organic pollutants (POPs) via multiple linear regressions. Consistent interaction was found between gender, ln oxychlordane and ln p,p' DDT. Also, we found an association between WC and ln oxychlordane and ln hpcdd in subjects with detectable levels of POPs, whereas an association between WC and ln p,p' DDT was observed in all subjects. Furthermore, ln Ocdd showed an increase with higher WC and BMI, whereas, ln trans-nonachlor decreased with higher BMI. Hence, BMI and WC are associated with POPs levels, making the chemicals plausible contributors to the obesity epidemic.
摘要
最近的证据表明，内分泌干扰化学物质（EDCs）可能会导致内源性激素调节紊乱，从而导致体重增加。本研究利用 NHANES（1999-2002 年）的数据，通过多元线性回归分析了体重指数（BMI）、腰围（WC）与选定持久性有机污染物（POPs）之间的关系。研究发现，性别、ln 氧氯丹和 ln p,p' DDT 之间存在一致性交互作用。此外，在可检测到 POPs 的人群中，WC 与 ln 氧氯丹和 ln hpcdd 之间存在关联，而在所有人群中，WC 与 ln p,p' DDT 之间存在关联。此外，lnOcdd 随着 WC 和 BMI 的升高而增加，而 ln 反式-十氯酮则随着 BMI 的升高而降低。因此，BMI 和 WC 与 POPs 水平相关，这些化学物质可能是肥胖流行的原因之一。
相似文献
1
Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999-2002 data.内分泌干扰物与肥胖：对 NHANES 1999-2002 数据中部分持久性有机污染物的检测。
Int J Environ Res Public Health. 2010 Jul;7(7):2988-3005. doi: 10.3390/ijerph7072988. Epub 2010 Jul 23.
2
Association of endocrine disruptors and obesity: perspectives from epidemiological studies.内分泌干扰物与肥胖的关联：来自流行病学研究的观点
Int J Androl. 2010 Apr;33(2):324-32. doi: 10.1111/j.1365-2605.2009.01035.x. Epub 2010 Jan 22.
3
Exposure of pregnant women to persistent organic pollutants and cord sex hormone levels.孕妇接触持久性有机污染物与脐带血性激素水平
Hum Reprod. 2016 Jan;31(1):190-8. doi: 10.1093/humrep/dev260. Epub 2015 Oct 22.
4
Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls.产前暴露于持久性有机氯污染物与 5 岁女童的高胰岛素水平有关。
Environ Res. 2015 Oct;142:407-13. doi: 10.1016/j.envres.2015.07.009. Epub 2015 Jul 30.
5
Persistent organic pollutants and mortality in the United States, NHANES 1999-2011.美国的持久性有机污染物与死亡率，1999 - 2011年美国国家健康与营养检查调查
Environ Health. 2017 Oct 10;16(1):105. doi: 10.1186/s12940-017-0313-6.
6
Low dose of some persistent organic pollutants predicts type 2 diabetes: a nested case-control study.低剂量某些持久性有机污染物可预测 2 型糖尿病：巢式病例对照研究。
Environ Health Perspect. 2010 Sep;118(9):1235-42. doi: 10.1289/ehp.0901480. Epub 2010 May 5.
7
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents.孕期暴露于持久性有机污染物与西班牙青少年肥胖和心血管代谢风险标志物的相关性研究
Environ Int. 2021 Jun;151:106469. doi: 10.1016/j.envint.2021.106469. Epub 2021 Mar 9.
8
Endocrine-disrupting chemicals and obesity development in humans: a review.内分泌干扰化学物质与人类肥胖症的发展：综述。
Obes Rev. 2011 Aug;12(8):622-36. doi: 10.1111/j.1467-789X.2011.00871.x. Epub 2011 Apr 4.
9
Ultra-processed food consumption and excess weight among US adults.美国成年人的超加工食品消费与超重。
Br J Nutr. 2018 Jul;120(1):90-100. doi: 10.1017/S0007114518001046. Epub 2018 May 6.
10
Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals--depot differences and dysmetabolism implications.肥胖个体人体内脏和皮下脂肪组织中持久性有机污染物水平——脂肪库差异及其对代谢失调的影响。
Environ Res. 2014 Aug;133:170-7. doi: 10.1016/j.envres.2014.05.026. Epub 2014 Jun 18.
引用本文的文献
1
Time to Consider the "Exposome Hypothesis" in the Development of the Obesity Pandemic.考虑“暴露组假说”在肥胖大流行发展中的作用。
Nutrients. 2022 Apr 12;14(8):1597. doi: 10.3390/nu14081597.
2
Obesity II: Establishing causal links between chemical exposures and obesity.肥胖症 II：建立化学暴露与肥胖之间的因果关系。
Biochem Pharmacol. 2022 May;199:115015. doi: 10.1016/j.bcp.2022.115015. Epub 2022 Apr 5.
3
Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Obesity.肥胖中内分泌干扰化学物质的表观遗传机制
Biomedicines. 2021 Nov 18;9(11):1716. doi: 10.3390/biomedicines9111716.
4
Endocrine Disrupting Chemicals, Transgenerational Epigenetics and Metabolic Diseases.内分泌干扰化学物质、跨代表观遗传学与代谢疾病
EC Endocrinol Metab Res. 2017 Nov;21:31-51.
5
Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases.环境内分泌干扰化学物质暴露：在非传染性疾病中的作用。
Front Public Health. 2020 Sep 24;8:553850. doi: 10.3389/fpubh.2020.553850. eCollection 2020.
6
Biomarkers of metabolic disorders and neurobehavioral diseases in a PCB- exposed population: What we learned and the implications for future research.代谢紊乱和神经行为疾病生物标志物在 PCB 暴露人群中的研究：我们的所得与未来研究的启示
Environ Res. 2020 Dec;191:110211. doi: 10.1016/j.envres.2020.110211. Epub 2020 Sep 13.
7
Markers of epithelial-mesenchymal transition in an experimental breast cancer model induced by organophosphorous pesticides and estrogen.有机磷农药和雌激素诱导的实验性乳腺癌模型中上皮-间质转化的标志物
Oncol Lett. 2020 Oct;20(4):84. doi: 10.3892/ol.2020.11945. Epub 2020 Aug 5.
8
Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population.巴基斯坦人群 2 型糖尿病的转录谱分析和生物学途径分析。
Int J Environ Res Public Health. 2020 Aug 13;17(16):5866. doi: 10.3390/ijerph17165866.
9
Endocrine disruptors from the environment affecting breast cancer.来自环境的内分泌干扰物影响乳腺癌。
Oncol Lett. 2020 Jul;20(1):19-32. doi: 10.3892/ol.2020.11566. Epub 2020 Apr 22.
10
Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis.接触内分泌干扰化学物质与肥胖人体测量指标：系统评价和荟萃分析。
BMJ Open. 2020 Jun 21;10(6):e033509. doi: 10.1136/bmjopen-2019-033509.
本文引用的文献
1
Dioxins and cardiovascular disease mortality.二噁英与心血管疾病死亡率
Environ Health Perspect. 2008 Nov;116(11):1443-8. doi: 10.1289/ehp.11579. Epub 2008 Jul 22.
2
Effects of endocrine disruptors on obesity.内分泌干扰物对肥胖的影响。
Int J Androl. 2008 Apr;31(2):201-8. doi: 10.1111/j.1365-2605.2007.00858.x.
3
Waist circumference values are increasing beyond those expected from BMI increases.腰围值的增长超过了根据体重指数增加所预期的数值。
Obesity (Silver Spring). 2007 Oct;15(10):2380-3. doi: 10.1038/oby.2007.282.
4
Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002.非糖尿病成年人血清中持久性有机污染物浓度与代谢综合征患病率之间的关系：1999 - 2002年美国国家健康与营养检查调查结果
Diabetologia. 2007 Sep;50(9):1841-1851. doi: 10.1007/s00125-007-0755-4. Epub 2007 Jul 12.
5
Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002.非糖尿病成年人血清中持久性有机污染物浓度与胰岛素抵抗之间的关联：1999 - 2002年美国国家健康与营养检查调查结果
Diabetes Care. 2007 Mar;30(3):622-8. doi: 10.2337/dc06-2190.
6
Developmental exposure to endocrine disruptors and the obesity epidemic.发育期接触内分泌干扰物与肥胖流行
Reprod Toxicol. 2007 Apr-May;23(3):290-6. doi: 10.1016/j.reprotox.2006.12.010. Epub 2007 Jan 17.
7
Persistent organic pollutants and the burden of diabetes.持久性有机污染物与糖尿病负担
Lancet. 2006 Aug 12;368(9535):558-9. doi: 10.1016/S0140-6736(06)69174-5.
8
Putative contributors to the secular increase in obesity: exploring the roads less traveled.肥胖率长期上升的潜在影响因素：探索鲜有人走的道路
Int J Obes (Lond). 2006 Nov;30(11):1585-94. doi: 10.1038/sj.ijo.0803326. Epub 2006 Jun 27.
9
A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002.持久性有机污染物血清浓度与糖尿病之间存在强烈的剂量反应关系：1999 - 2002年美国国家健康与营养检查调查结果
Diabetes Care. 2006 Jul;29(7):1638-44. doi: 10.2337/dc06-0543.
10
Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations.典型环境雌激素己烯雌酚的不良反应会遗传给后代。
Endocrinology. 2006 Jun;147(6 Suppl):S11-7. doi: 10.1210/en.2005-1164. Epub 2006 May 11.
Zotero 插件