Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK.
Clin Exp Allergy. 2011 Jan;41(1):78-85. doi: 10.1111/j.1365-2222.2010.03598.x. Epub 2010 Aug 16.
The increase in allergic diseases has occurred in parallel with the obesity epidemic, suggesting a possible association.
We investigated the relationship of body mass index (BMI) up to age 8 years with allergic disease within a birth cohort.
Children were followed from birth and were reviewed at age 3, 5 and 8 years (n=731; male 406). Parents completed questionnaires; children were weighed, measured, skin prick tested and examined.
Increasing BMI at 3, 5 and 8 years increased the risk of current wheezing at the corresponding age (odds ratio [95% confidence interval] per standardized deviation score: age 3, 1.26 [1.04-1.53], P=0.02; age 5, 1.33 [1.06-1.67], P=0.02; age 8, 1.27 [1.0-1.62], P=0.05). The effect of BMI on wheeze at age 8 years differed between boys and girls, with a significant positive association in girls, but not in boys (P=0.04 for interaction). The effect of BMI at earlier ages on current or subsequent wheezing did not differ significantly between genders. Increasing BMI significantly increased the risk of physician-diagnosed eczema at age 5 (1.23 [1.04-1.47], P=0.02) and 8 (1.23 [1.03-1.45], P=0.02), with a significant interaction between gender and BMI at age 5 (P=0.04). There was no association between BMI and sensitization. Being overweight at age 3 years was significantly associated with late-onset wheeze (3.83 [1.51-9.75], P=0.005), persistent wheeze (4.15 [2.07-8.32], P<0.001) and persistent eczema (1.79 [1.03-3.13], P=0.04) in both boys and girls.
Being overweight is associated with an increased risk of allergic disease in childhood. However, the strength of the association varies with the gender, age and atopic phenotype.
过敏疾病的增加与肥胖症的流行同时发生，这表明两者之间可能存在关联。
我们在一个出生队列中调查了 8 岁以下儿童的体重指数（BMI）与过敏性疾病之间的关系。
对儿童进行了从出生到 3 岁、5 岁和 8 岁的随访（n=731；男性 406 人）。父母完成了问卷调查；对儿童进行了称重、测量、皮肤点刺试验和检查。
3 岁、5 岁和 8 岁时 BMI 的增加增加了相应年龄时当前喘息的风险（每标准差评分的优势比[95%置信区间]：年龄 3 岁，1.26[1.04-1.53]，P=0.02；年龄 5 岁，1.33[1.06-1.67]，P=0.02；年龄 8 岁，1.27[1.00-1.62]，P=0.05）。BMI 对 8 岁时喘息的影响在男孩和女孩之间存在差异，女孩存在显著的正相关，而男孩则没有（性别与 BMI 之间的交互作用 P=0.04）。在男孩和女孩之间，BMI 对早期喘息或随后喘息的影响没有显著差异。BMI 的增加显著增加了 5 岁时（1.23[1.04-1.47]，P=0.02）和 8 岁时（1.23[1.03-1.45]，P=0.02）医生诊断为特应性皮炎的风险，性别与 5 岁时 BMI 之间存在显著的交互作用（P=0.04）。BMI 与过敏症之间没有关联。3 岁时超重与迟发性喘息（3.83[1.51-9.75]，P=0.005）、持续性喘息（4.15[2.07-8.32]，P<0.001）和持续性特应性皮炎（1.79[1.03-3.13]，P=0.04）显著相关，无论男孩还是女孩均如此。
超重与儿童时期过敏性疾病的风险增加有关。然而，关联的强度因性别、年龄和特应性表型而异。
