Department of Dermatology, The People's Hospital of Baoshan, Baoshan, Yunnan, China.
Dermatology Service, Veterans Affairs Medical Center San Francisco, and Department of Dermatology, University of California, San Francisco, California, USA.
Exp Dermatol. 2023 Jul;32(7):975-985. doi: 10.1111/exd.14801. Epub 2023 Apr 7.
Two serious health conditions, obesity and atopic dermatitis (AD), share some pathological features such as insulin resistance, leptin resistance and inflammation, and a growing body of evidence suggests a link between obesity and AD. Obesity predisposes an individual to and/or worsens AD, whereas AD increases the risk of obesity. Obesity and AD's interactions are mediated by cytokines, chemokines and immune cells. Obese individuals with AD are more resistant to anti-inflammatory therapy, while weight loss can alleviate AD. In this review, we summarize the evidence linking AD and obesity. We also discuss the pathogenic role of obesity in AD, and vice versa. Because of the connection between these two conditions, mitigation of one could possibly prevent the development of or alleviate the other condition. Effective management of AD and weight loss can enhance the wellness of individuals with both of these conditions. However, proper clinical studies are warranted to validate this speculation.
两种严重的健康状况，肥胖症和特应性皮炎（AD），具有一些共同的病理特征，如胰岛素抵抗、瘦素抵抗和炎症，越来越多的证据表明肥胖症和 AD 之间存在关联。肥胖症使个体易患 AD 或使 AD 恶化，而 AD 则增加肥胖症的风险。肥胖症和 AD 的相互作用是由细胞因子、趋化因子和免疫细胞介导的。患有 AD 的肥胖个体对抗炎治疗的反应更差，而减肥可以缓解 AD。在这篇综述中，我们总结了 AD 和肥胖症之间关联的证据。我们还讨论了肥胖症在 AD 中的发病作用，反之亦然。由于这两种情况之间存在联系，减轻其中一种情况可能会预防或缓解另一种情况。有效管理 AD 和减肥可以提高同时患有这两种疾病的个体的健康水平。然而，需要进行适当的临床研究来验证这一推测。
