通过序列基检测，在一名巴西志愿骨髓捐赠者中发现了一个新的等位基因 HLA-B*4212。
A new allele, HLA-B*4212, identified in a Brazilian volunteer bone marrow donors by sequence-based typing.
机构信息
Laboratory of Immunogenetics and Histocompatibility, Genetics Department, Universidade Federal do Paraná, Curitiba, Brazil.
出版信息
Int J Immunogenet. 2010 Dec;37(6):517-8. doi: 10.1111/j.1744-313X.2010.00950.x.
Abstract
Here we report the discovery of a novel HLA-B allele, named B4212 in a Brazilian volunteer bone marrow donor. The new sequence has nucleotide variation at position 496 (T→G) as compared with B4201. This variation results in a conservative amino acid substitution from valine to glycine at codon 165 of exon 3.
摘要
在这里，我们报道了在一名巴西志愿者骨髓供者中发现了一种新的 HLA-B 等位基因，命名为 B4212。与 B4201 相比，新序列在第 496 位（T→G）有核苷酸变异。这种变异导致第 3 外显子的 165 密码子处的缬氨酸保守性氨基酸取代为甘氨酸。
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