Lei Zhe, Liu Rengyun, Chen Jun, Zhou Qinghua, Zhang Hongtao
Laboratory of Medical Genetics, School of Basic Medicine & Biological Sciences, Medical College of Soochow University, Suzhou 215123, China.
Zhongguo Fei Ai Za Zhi. 2009 May 20;12(5):381-6. doi: 10.3779/j.issn.1009-3419.2009.05.017.
Lung cancer is one of the most common cancers worldwide, especially in China. It has been proved that matrix metalloproteases (MMPs) play a key role in malignant cell metastasis. There have been a considerable number of studies investigating MMP polymorphisms in relation to various cancers. However, the associations of MMP polymorphisms with risk of lung cancer are lack of consistency. The aim of this study is to assess the association of MMP polymorphisms with risk of lung cancer by conducting a Meta -analysis from all eligible casecontrol studies published to date.
To identify all studies that examined the association of polymorphisms in the promoter of MMP1, MMP2 and MMP9 with lung cancer, we conducted a computerized literature search of PubMed and MEDLINE database (before March, 2009). Two investigators independently extracted the data and reached a consensus on all items.
Eight case-control studies, including 4 467 lung cancer cases and 4 051 controls, were selected for Meta -analysis to better assess the purported associations of common MMPs polymorphisms with risk of lung cancer. Our results suggest that MMP2 -735C/T polymorphism is significantly modified risk of lung cancer. Comparing with the wild -735C allele, the variant T allele decreased risk of developing lung cancer (OR=0.72, 95%CI: 0.61-0.85, P =0.0001). Other polymorphisms, including MMP1 -1607 1G/2G, MMP2 -1306C/T and MMP9 -1562C/T, are not associated with risk of lung cancer.
The present study indicates that the MMP2 -735C/T polymorphism is associated with the risk of lung cancer. Lager studies should be required to warrant the association of MMP9 -1562C/T polymorphism with risk of lung cancer.
肺癌是全球最常见的癌症之一，在中国尤为如此。已证实基质金属蛋白酶（MMPs）在恶性细胞转移中起关键作用。已有大量研究调查MMP多态性与各种癌症的关系。然而，MMP多态性与肺癌风险的关联缺乏一致性。本研究的目的是通过对迄今为止发表的所有符合条件的病例对照研究进行Meta分析，评估MMP多态性与肺癌风险的关联。
为了识别所有研究MMP1、MMP2和MMP9启动子多态性与肺癌关联的研究，我们对PubMed和MEDLINE数据库（截至2009年3月）进行了计算机文献检索。两名研究人员独立提取数据，并就所有项目达成共识。
八项病例对照研究，包括4467例肺癌病例和4051例对照，被选入Meta分析，以更好地评估常见MMP多态性与肺癌风险的所谓关联。我们的结果表明，MMP2 -735C/T多态性显著改变了肺癌风险。与野生型-735C等位基因相比，变异型T等位基因降低了患肺癌的风险（OR=0.72，95%CI：0.61 - 0.85，P =0.0001）。其他多态性，包括MMP1 -1607 1G/2G、MMP2 -1306C/T和MMP9 -1562C/T，与肺癌风险无关。
本研究表明，MMP2 -735C/T多态性与肺癌风险相关。需要更大规模的研究来证实MMP9 -1562C/T多态性与肺癌风险的关联。
