Li Hongxia, Liang Xiaoyan, Qin Xuebing, Cai Shaohua, Yu Senyang
Department of Respiratory Medicine, South Building, Chinese PLA General Hospital, Beijing 100853.
Department of Respiratory Medicine, Special Inpatient Unit, Chinese PLA General Hospital, Beijing 100853.
Sci Rep. 2015 Jul 22;5:10056. doi: 10.1038/srep10056.
Many studies have reported the association between the matrix metalloproteinase (MMP) polymorphisms and lung cancer susceptibility, but the results were inconclusive. We conducted a meta-analysis, using a comprehensive strategy based on the logistic regression and a model-free approach, to derive a more precise estimation of the relationship between MMP1, MMP2, MMP9 and MMP13 polymorphisms with lung cancer risk. A total of 22 case-control studies including 8202 cases and 7578 controls were included in this meta-analysis. For MMP1-1607 1G/2G, increased lung cancer risk was found among Asians in additive model(OR = 1.34, 95%CI:1.18-1.53) and with model-free approach(ORG = 1.41, 95%CI:1.21-1.65). For MMP2-1306 C/T and -735 C/T, based on the model-free approach, a significantly reduced risk was found in Asians(MMP2-1306 C/T:ORG = 0.49,95%CI:0.42-0.57; MMP2-735 C/T: ORG = 0.71, 95%CI:0.61-0.84). For MMP9-1562 C/T, a significantly increased risk was found among Asians(OR = 2.73, 95%CI:1.74-4.27) with model-free approach. For MMP13-77A/G, there was no association between this polymorphism and lung cancer risk in the recessive model(OR = 1.02, 95%CI:0.83-1.26) and with the model-free approach(ORG = 0.95, 95%CI:0.76-1.17). Therefore, this meta-analysis suggests that the MMP1-1607 1G/2G, MMP2-1306 C/T, MMP2-735 C/T, MMP9 -1562 C/T polymorphisms were risk factors for lung cancer among Asians, while MMP13 -77A/G polymorphism was not associated with lung cancer risk.
许多研究报告了基质金属蛋白酶（MMP）基因多态性与肺癌易感性之间的关联，但结果尚无定论。我们采用基于逻辑回归和无模型方法的综合策略进行了一项荟萃分析，以更精确地估计MMP1、MMP2、MMP9和MMP13基因多态性与肺癌风险之间的关系。该荟萃分析共纳入22项病例对照研究，包括8202例病例和7578例对照。对于MMP1 - 1607 1G/2G，在亚洲人群中，相加模型显示肺癌风险增加（OR = 1.34，95%CI：1.18 - 1.53），无模型方法显示风险增加（ORG = 1.41，95%CI：1.21 - 1.65）。对于MMP2 - 1306 C/T和 - 735 C/T，基于无模型方法，在亚洲人群中发现风险显著降低（MMP2 - 1306 C/T：ORG = 0.49，95%CI：0.42 - 0.57；MMP2 - 735 C/T：ORG = 0.71，95%CI：0.61 - 0.84）。对于MMP9 - 1562 C/T，无模型方法显示亚洲人群中风险显著增加（OR = 2.73，95%CI：1.74 - 4.27）。对于MMP13 - 77A/G基因多态性，在隐性模型（OR = 1.02，95%CI：0.83 - 1.26）和无模型方法（ORG = 0.95，95%CI：0.76 - 1.17）中，该多态性与肺癌风险无关联。因此，这项荟萃分析表明，MMP1 - 1607 1G/2G、MMP2 - 1306 C/T、MMP2 - 735 C/T、MMP9 - 1562 C/T基因多态性是亚洲人群肺癌的危险因素，而MMP13 - 77A/G基因多态性与肺癌风险无关。
