Li Shenjiang, Xiao Xiangsheng, Liu Shiyuan, Li Chengzhou, Zhang Chenshi
Department of Imageology, The Eighty-eighth Military Hospital, Tai'an 271000, China.
Zhongguo Fei Ai Za Zhi. 2009 May 20;12(5):426-9. doi: 10.3779/j.issn.1009-3419.2009.05.009.
The solitary pulmonary nodules (SPNs) is one of the most common findings on chest radiographs. The blood flow patterns of the biggest single SPNs level has been studied. This assessment may be only a limited sample of the entire region of interest (ROI) and is unrepresentative of the SPNs as a volume. Ideally, SPNs volume perfusion should be measured. The aim of this study is to evaluate the correlation between the quantifiable parameters of SPNs volume perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT and nodules size.
Sixty-five patients with SPNs (diameter<=3 cm; 42 malignant; 12 active inflammatory; 11 benign) underwent multi-location dynamic contrast material-enhanced serial CT scanning mode with stable table were performed; The mean values of valid sections were calculated, as the quantifiable parameters of volume SPNs perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT. The correlation between the quantifiable parameters of SPNs volume perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT and nodules size were assessed by means of linear regression analysis.
No significant correlations were found between the nodules size and each of the peak height (PHSPN) (32.15 Hu+/-14.55 Hu),ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio) (13.20+/-6.18)%, perfusion (PSPN) (29.79+/-19.12) mLmin(-1)100 g(-1) and mean transit time (12.95+/-6.53) s (r =0.081, P =0.419; r =0.089, P =0.487; r =0.167, P =0.077; r =0.023, P =0.880).
No significant correlations were found between the quantifiable parameters of SPNs volume perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT and nodules size.
孤立性肺结节（SPN）是胸部X线片上最常见的表现之一。已对最大单个SPN层面的血流模式进行了研究。这种评估可能只是整个感兴趣区域（ROI）的有限样本，不能代表SPN的整体情况。理想情况下，应测量SPN的体积灌注。本研究的目的是评估16层螺旋CT和64层螺旋CT得出的SPN体积灌注成像的可量化参数与结节大小之间的相关性。
65例SPN患者（直径<=3 cm；42例恶性；12例活动性炎症；11例良性）采用稳定检查床的多部位动态对比剂增强序列CT扫描模式；计算有效层面的平均值，作为16层螺旋CT和64层螺旋CT得出的SPN体积灌注成像的可量化参数。通过线性回归分析评估16层螺旋CT和64层螺旋CT得出的SPN体积灌注成像的可量化参数与结节大小之间的相关性。
未发现结节大小与峰值高度（PHSPN）（32.15 Hu±14.55 Hu）、SPN与主动脉峰值高度之比（SPN-to-A ratio）（13.20±6.18）%、灌注（PSPN）（29.79±19.12）mLmin(-1)100 g(-1)和平均通过时间（12.95±6.53）s之间存在显著相关性（r =0.081，P =0.419；r =0.089，P =0.487；r =0.167，P =0.077；r =0.023，P =0.880）。
未发现16层螺旋CT和64层螺旋CT得出的SPN体积灌注成像的可量化参数与结节大小之间存在显著相关性。
