Li Shenjiang, Xiao Xiangsheng, Liu Shiyuan, Li Huimin, Li Chengzhou, Zhang Chenshi
Department of Imageology , The Eighty-eighth Military Hospital ,Taian, Shandong 271000 ,China.
Zhongguo Fei Ai Za Zhi. 2008 Feb 20;11(1):74-8. doi: 10.3779/j.issn.1009-3419.2008.01.017.
The solitary pulmonary nodules (SPNs ) is one of the most common findings on chest radiographs. It becomes possible to provide more accurately quantitative information about blood flow patterns of solitary pulmonary nodules (SPNs ) with multi-slice spiral computed tomography (MSCT). The aim of this study is to evaluate the correlation between the quantifiable parameters of blood flow pattern derived with dynamic CT in maliagnant solitary pulmonary nodules and tumor size.
68 patients with maliagnant solitary pulmonary nodules (SPNs ) (diameter <=4 cm)underwent multi-location dynamic contrast material-enhanced (nonionic contrast material was administrated via the antecubital vein at a rate of 4mL/s by an autoinjector, 45mm or 42.5mm scanning mode with stable table were performed.) serial CT. Precontrast and postcontrast attenuation on every scan was recorded. Perfusion (PSPN), peak height (PHSPN), ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio)and mean transit time(MTT) were calculated. The correlation between the quantifiable parameters of blood flow pattern derived with dynamic CT in maliagnant solitary pulmonary nodules and tumor size were assessed by means of linear regression analysis.
No significant correlations were found between the tumor size and each of the peak height (PHSPN), ratio of peak height of the SPN to that of the aorta (SPN-to-A ratio), perfusion (PSPN)and mean transit time(r=0.18,P=0.14; r=0.20,P=0.09; r=0.01, P=0.95; r=0.01, P=0.93).
No significant correlation is found between the tumor size and each of the quantifiable parameters of blood flow pattern derived with dynamic CT in maliagnant solitary pulmonary nodules.
孤立性肺结节（SPN）是胸部X线片上最常见的表现之一。多层螺旋计算机断层扫描（MSCT）能够更准确地提供有关孤立性肺结节（SPN）血流模式的定量信息。本研究旨在评估动态CT得出的恶性孤立性肺结节血流模式的可量化参数与肿瘤大小之间的相关性。
68例恶性孤立性肺结节（SPN）（直径≤4 cm）患者接受了多部位动态对比剂增强CT扫描（通过自动注射器经肘前静脉以4 mL/s的速率注入非离子型对比剂，采用4×5 mm或4×2.5 mm扫描模式，扫描时检查床保持稳定）。记录每次扫描的平扫和增强扫描后的衰减值。计算灌注（PSPN）、峰值高度（PHSPN）、SPN与主动脉峰值高度之比（SPN与A之比）和平均通过时间（MTT）。通过线性回归分析评估动态CT得出的恶性孤立性肺结节血流模式的可量化参数与肿瘤大小之间的相关性。
未发现肿瘤大小与峰值高度（PHSPN）、SPN与主动脉峰值高度之比（SPN与A之比）、灌注（PSPN）及平均通过时间中的任何一项存在显著相关性（r = 0.18，P = 0.14；r = 0.20，P = 0.09；r = 0.01，P = 0.95；r = 0.01，P = 0.93）。
在恶性孤立性肺结节中，未发现肿瘤大小与动态CT得出的血流模式可量化参数中的任何一项存在显著相关性。
