裂殖酵母中线粒体依赖微管的空间组织

Microtubule-dependent spatial organization of mitochondria in fission yeast.

作者信息

Das Maitreyi, Chiron Stéphane, Verde Fulvia

机构信息

Department of Molecular and Cellular Pharmacology (R-189), University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

出版信息

Methods Cell Biol. 2010;97:203-21. doi: 10.1016/S0091-679X(10)97012-X.

DOI:10.1016/S0091-679X(10)97012-X

PMID:20719273

Abstract

The microtubule cytoskeleton has an important role in the control of mitochondrial distribution in higher eukaryotes. In humans, defects in axonal mitochondrial transport are linked to neurodegenerative diseases. This chapter highlights fission yeast Schizosaccharomyces pombe as a powerful genetic model system for the study of microtubule-dependent mitochondrial movement, dynamics and inheritance.

摘要

微管细胞骨架在高等真核生物中线粒体分布的控制方面发挥着重要作用。在人类中，轴突线粒体运输缺陷与神经退行性疾病相关。本章重点介绍了粟酒裂殖酵母，它是用于研究微管依赖性线粒体运动、动态变化及遗传的强大遗传模型系统。