Thornton M J, Messenger A G, Elliott K, Randall V A
Department of Biomedical Sciences, University of Bradford, West Yorkshire, U.K.
J Invest Dermatol. 1991 Aug;97(2):345-8. doi: 10.1111/1523-1747.ep12480688.
Androgens stimulate hair growth in some areas, e.g., beard, but may cause regression and baldness on the scalp. The mesenchyme-derived dermal papilla is believed to regulate many aspects of hair growth. It is probable that androgens exert their effect on hair growth via the dermal papilla. In this study the effect of androgens on the growth of cultured dermal papilla cells from beard and non-balding scalp was assessed. Dermal papilla cells from beard hair follicles and non-balding scalp were cultured in vitro in the presence and absence of different concentrations of testosterone or the synthetic, non-metabolizable androgen, mibolerone. Cell growth was reflected by the incorporation of 3H-thymidine. The presence of either androgen did not significantly alter DNA synthesis at any of the concentrations examined in either type of cell line. These results do not mean that dermal papilla cells do not respond to androgens in vitro, but that the measurement of cell growth is an inappropriate method of assessment. Androgens may well stimulate the synthesis of specific proteins that could influence the hair follicle.
雄激素可刺激某些部位的毛发生长，如胡须，但可能导致头皮毛发脱落和秃发。间充质来源的真皮乳头被认为可调节毛发生长的多个方面。雄激素可能通过真皮乳头对毛发生长发挥作用。在本研究中，评估了雄激素对来自胡须和非秃头皮的培养真皮乳头细胞生长的影响。将来自胡须毛囊和非秃头皮的真皮乳头细胞在有和没有不同浓度睾酮或合成的、不可代谢的雄激素米勃龙的情况下进行体外培养。通过掺入³H-胸腺嘧啶核苷反映细胞生长。在任何一种细胞系中，在所检测的任何浓度下，两种雄激素的存在均未显著改变DNA合成。这些结果并不意味着真皮乳头细胞在体外不响应雄激素，而是细胞生长的测量是一种不恰当的评估方法。雄激素很可能刺激可影响毛囊的特定蛋白质的合成。
