Sermet-Gaudelus I, Munck A, Rota M, Roussey M, Feldmann D, Nguyen-Khoa T
Inserm U 845, centre de ressources et de compétences de la mucoviscidose, hôpital Necker, université René Descartes, 156, rue de Vaugirard, 75730 Paris, France.
Arch Pediatr. 2010 Sep;17(9):1349-58. doi: 10.1016/j.arcped.2010.06.021. Epub 2010 Aug 16.
These guidelines aim to standardize the standard operating procedures for the sweat test in newborn cystic fibrosis (CF) screening. They have been implemented by the national Neonatal Screening working group of the French Federation for Cystic Fibrosis. It is recommended that the sweat test be performed when the infant weighs more than 3 kg and is at least 3 weeks of age. Sweat gland secretion is stimulated by transdermal administration of pilocarpine by iontophoresis. Sweat is preferentially collected in a Macroduct coil. Diagnosis of CF is based on the sweat chloride level. A sweat chloride level below 30 mmol/l very probably rules out CF; 60 mmol/l or higher supports the diagnosis of CF. Values between 30 and 60 mmol/l are considered abnormal.
这些指南旨在规范新生儿囊性纤维化（CF）筛查中汗液测试的标准操作程序。它们已由法国囊性纤维化联合会的国家新生儿筛查工作组实施。建议在婴儿体重超过3千克且至少3周龄时进行汗液测试。通过离子电渗疗法经皮给予毛果芸香碱刺激汗腺分泌。汗液优先收集在Macroduct线圈中。CF的诊断基于汗液氯化物水平。汗液氯化物水平低于30 mmol/l很可能排除CF；60 mmol/l或更高则支持CF的诊断。30至60 mmol/l之间的值被视为异常。
