半胱氨酰白三烯受体拮抗作用可减弱猫对内毒素的急性降压反应。
Cysteinyl-leukotriene receptor antagonism blunts the acute hypotensive response to endotoxin in cats.
作者信息
DeClue Amy E, Sharp Claire R, Cohen Rachael L, Leverenz Elizabeth F, Reinero Carol R
机构信息
Department of Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA.
出版信息
J Feline Med Surg. 2010 Oct;12(10):754-9. doi: 10.1016/j.jfms.2010.05.012. Epub 2010 Aug 16.
This study evaluated the effects of a cysteinyl-leukotriene-1 (cys-LT(1)) receptor antagonist, zarfirlukast, during feline endotoxemia. Six adult, sexually intact male cats received either placebo or zarfirlukast (10mg, PO) and endotoxin (2 μg/kg/h q 6h) in a cross-over design. Rectal temperature, heart rate, systolic arterial blood pressure, plasma tumor necrosis factor (TNF) activity, interleukin (IL)-6 concentration and urine cys-LT to creatinine ratio were evaluated. The rectal temperature, plasma TNF activity and IL-6 concentrations were significantly higher and systolic arterial blood pressure and heart rate significantly lower after endotoxin infusion. Cats treated with zafirlukast had a significantly higher blood pressure at 4h (P=0.002) compared to placebo. Urine cys-LT to creatinine ratio was significantly greater in the cats treated with zafirlukast compared to placebo (P=0.02). Zafirlukast administration ameliorated the acute hypotensive response to endotoxin in cats, but failed to significantly alter rectal temperature, heart rate or production of TNF and IL-6.
本研究评估了半胱氨酰白三烯-1（cys-LT(1)）受体拮抗剂扎鲁司特在猫内毒素血症期间的作用。采用交叉设计，6只成年、未绝育的雄性猫分别接受安慰剂或扎鲁司特（10mg，口服）以及内毒素（2μg/kg/h，每6小时一次）。评估了直肠温度、心率、收缩期动脉血压、血浆肿瘤坏死因子（TNF）活性、白细胞介素（IL）-6浓度以及尿中半胱氨酰白三烯与肌酐的比值。内毒素输注后，直肠温度、血浆TNF活性和IL-6浓度显著升高，收缩期动脉血压和心率显著降低。与安慰剂相比，接受扎鲁司特治疗的猫在4小时时血压显著更高（P=0.002）。与安慰剂相比，接受扎鲁司特治疗的猫尿中半胱氨酰白三烯与肌酐的比值显著更高（P=0.02）。给予扎鲁司特可改善猫对内毒素的急性低血压反应，但未能显著改变直肠温度、心率或TNF和IL-6的产生。
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