Department of Biological Chemistry and Department of Developmental and Cell Biology, University of California, Irvine, California 92697-4037, USA.
Cold Spring Harb Perspect Biol. 2010 Oct;2(10):a003236. doi: 10.1101/cshperspect.a003236. Epub 2010 Aug 18.
Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes. This article describes several key oncogene and tumor suppressor signaling networks that have been implicated in breast cancer progression. Among the tumor suppressors, the article emphasizes BRCA1/2 and p53 tumor suppressors. In addition to these well characterized tumor suppressors, the article highlights the importance of PTEN tumor suppressor in counteracting PI3K signaling from activated oncogenes such as ErbB2. This article discusses the use of mouse models of human breast that recapitulate the key genetic events involved in the initiation and progression of breast cancer. Finally, the therapeutic potential of targeting these key tumor suppressor and oncogene signaling networks is discussed.
乳腺癌的进展涉及多个遗传事件，这些事件可激活显性作用的癌基因并破坏特定肿瘤抑制基因的功能。本文描述了几种关键的癌基因和肿瘤抑制信号网络，这些信号网络与乳腺癌的进展有关。在肿瘤抑制因子中，本文强调了 BRCA1/2 和 p53 肿瘤抑制因子。除了这些特征明确的肿瘤抑制因子外，本文还强调了 PTEN 肿瘤抑制因子在对抗激活的癌基因（如 ErbB2）的 PI3K 信号方面的重要性。本文讨论了使用模拟人类乳腺癌中涉及癌症起始和进展的关键遗传事件的人类乳腺癌小鼠模型。最后，讨论了针对这些关键肿瘤抑制因子和癌基因信号网络的治疗潜力。
