Khairi Sabiah, Wang Chih-Yang, Anuraga Gangga, Prayugo Fidelia Berenice, Ansar Muhamad, Lesmana Mohammad Hendra Setia, Irham Lalu Muhammad, Shen Chen-Yang, Chung Min-Huey
School of Nursing, College of Nursing, Taipei Medical University, Taipei City 11031, Taiwan.
Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei City 11031, Taiwan.
J Pers Med. 2025 Mar 30;15(4):134. doi: 10.3390/jpm15040134.
Biopsychosocial factors, including family history, influence the development of breast cancer. Malignancies in women with a family history of breast cancer may be detectable based on DNA methylation and microRNA. : The present study extended an integrative analysis of DNA methylation and microRNA to identify genes associated with biopsychosocial factors. : We identified 3060 healthy women from the Taiwan Biobank and included 32 blood plasma samples for analysis of biopsychosocial factors and epigenetic changes. GEO databases and bioinformatics approaches were used for the identification and validation of potential genes. : Our integrative analysis revealed GNPDA1 and SLC25A16 as potential genes. Age, a family history of cancer, and alcohol consumption were associated with GNPDA1 and SLC25A16 based on the current data set and the GEO data set. GNPDA1 and SLC25A16 exhibited significant expression in breast cancer tissues based on UALCAN analysis, where they were overexpressed and underexpressed, respectively. Through a MethSurv analysis, GNPDA1 hypomethylation and SLC25A16 hypermethylation were associated with poor prognoses in terms of overall survival in breast cancer. Moreover, through a MetaCore functional enrichment analysis, GNPDA1 and SLC25A16 were associated with the BRCA1, BRCA2, and pro-oncogenic actions of the androgen receptor in breast cancer. Further, GNPDA1 and SLC25A16 were enriched in known targets of approved cancer drugs as potential genes associated with breast cancer. : These two genes might serve as biomarkers for the early detection of breast cancer, especially for women with a family history of breast cancer.
生物心理社会因素，包括家族病史，会影响乳腺癌的发展。对于有乳腺癌家族病史的女性，基于DNA甲基化和微小RNA，其恶性肿瘤可能可被检测到。本研究扩展了对DNA甲基化和微小RNA的综合分析，以识别与生物心理社会因素相关的基因。我们从台湾生物银行中确定了3060名健康女性，并纳入32份血浆样本用于生物心理社会因素和表观遗传变化分析。利用基因表达综合数据库（GEO）和生物信息学方法来识别和验证潜在基因。我们的综合分析揭示了GNPDA1和SLC25A16为潜在基因。根据当前数据集和GEO数据集，年龄、癌症家族病史和饮酒与GNPDA1和SLC25A16相关。基于UALCAN分析，GNPDA1和SLC25A16在乳腺癌组织中分别表现出显著的过表达和低表达。通过甲基化生存分析（MethSurv），就乳腺癌的总生存期而言，GNPDA1低甲基化和SLC25A16高甲基化与不良预后相关。此外，通过MetaCore功能富集分析，GNPDA1和SLC25A16与乳腺癌中的BRCA1、BRCA2以及雄激素受体的促癌作用相关。此外，作为与乳腺癌相关的潜在基因，GNPDA1和SLC25A16在已获批癌症药物的已知靶点中富集。这两个基因可能作为乳腺癌早期检测的生物标志物，尤其是对于有乳腺癌家族病史的女性。
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