Beijing Obstetric and Gynecology Hospital, Capital Medical University, Beijing, China.
Cancer Epidemiol Biomarkers Prev. 2010 Oct;19(10):2655-64. doi: 10.1158/1055-9965.EPI-10-0212. Epub 2010 Aug 18.
Few population-based studies have investigated premalignant and malignant cervical abnormalities in Beijing.
A total of 6,385 randomly selected sexually active women were interviewed and examined. Cervical lesion was diagnosed using cytology and histology. High-risk human papillomavirus (HPV) was detected by the second-generation hybrid capture test and typed by gene chip of DNA from paraffin-embedded tissue.
The cervical lesion prevalence diagnosed by histology was 5.8%. High-risk HPV overall prevalence was 9.9%, 50.5% with cervical lesion and 7.4% without cervical lesion. High-risk HPV DNA load increased with increasing degree of lesions. HPV 16 was the most common type (26.5%) among women with cervical lesion, followed by HPV 58 (8.8%), HPV 33 (7.8%), and HPV 56 (5.3%). Women under 50 years of age, married status, pregnancy and delivery status, couple's sexual behavior, contraceptive history, columnar ectopy, and bacterial vaginosis or trichomonas vaginitis history were more risk factors for HPV infection. Factors for cervical lesion were similar, but in comparison with HPV infection, all associations were weakened. Only middle-aged women, husband's sexual partners, oral contraceptives, columnar ectopy, and history of trichomonas vaginitis remained associated with cervical lesion.
In Beijing, the prevalence of cervical lesion and high-risk HPV is higher than estimated in previous reports. HPV 16, 58, and 33 were the most prevalent types. This is relevant for work related to cervical cancer vaccination.
The study was conducted to understand the current status and epidemiologic characteristics of women with cervical lesion and HPV infection in Beijing.
很少有基于人群的研究调查过北京地区的宫颈前病变和恶性肿瘤。
共对 6385 名随机选择的有性生活的女性进行了访谈和检查。通过细胞学和组织学诊断宫颈病变。高危型人乳头瘤病毒（HPV）采用第二代杂交捕获法检测，石蜡包埋组织 DNA 的基因芯片法进行 HPV 型别鉴定。
组织学诊断的宫颈病变患病率为 5.8%。高危型 HPV 总感染率为 9.9%，其中有宫颈病变者为 50.5%，无宫颈病变者为 7.4%。高危型 HPV DNA 载量随病变程度增加而增加。HPV 16 是宫颈病变患者中最常见的类型（26.5%），其次是 HPV 58（8.8%）、HPV 33（7.8%）和 HPV 56（5.3%）。年龄<50 岁、已婚、妊娠和分娩、性伴侣、避孕史、柱状上皮异位、细菌性阴道病或滴虫性阴道炎史是 HPV 感染的危险因素。与 HPV 感染相似，宫颈病变的危险因素也是如此，但与 HPV 感染相比，所有关联均减弱。只有中年女性、丈夫的性伴侣、口服避孕药、柱状上皮异位和滴虫性阴道炎史与宫颈病变相关。
在北京，宫颈病变和高危型 HPV 的患病率高于以往报道。HPV 16、58 和 33 是最常见的类型。这与宫颈癌疫苗接种相关工作有关。
本研究旨在了解北京地区女性宫颈病变和 HPV 感染的现状和流行病学特征。
