Hospital General Virgen del Rocío, Service of Internal Medicine, Virgen del Rocío University Hospital, Manuel Siurot s/n, Seville, Spain.
Hypertens Res. 2010 Oct;33(10):1012-7. doi: 10.1038/hr.2010.131. Epub 2010 Aug 19.
To measure high-sensitivity C-reactive protein (hsCRP) levels and to assess the presence of metabolic syndrome (MS) after puerperium in women diagnosed with various hypertensive disorders during pregnancy (HDP), a consecutive, cross-sectional case study at the 15th week after gestation. The sample consisted of 264 women who were admitted to a women's hospital. The diagnoses consisted of transient gestational hypertension (TGH=43.2%), preeclampsia (PC=29.5%), chronic hypertension (CH=20.1%) and PC superimposed on CH (7.2%). A diagnosis of previous hypertension was present in 45.8% of the CH group. The prevalence of MS was 16.7% (CH=42.1%, TGH=13.9%, PC=4.1%, P<0.001). The average hsCRP levels for the CH, TGH and PC groups were 3.79 ± 2.76, 3.55 ± 3.15 and 2.89 ± 3.02, respectively (P=0.040). The levels of hsCRP were higher in women with MS (4.71 ± 3.15 vs. 3.01 ± 2.88 mg l(-1) in those without MS, P<0.001), and they increased when a higher number of MS criteria was fulfilled (P<0.001). The results demonstrated a positive correlation between hsCRP levels and body mass index (BMI) (r=0.46), waist circumference (r=0.50) or the number of fulfilled MS criteria (r=0.56). The results suggest differences in vascular risk that depend on the type of HDP and on the prevalence of MS. The prevalence of MS was notably higher in the CH group, intermediate among the TGH group and much lower in the PC group. Differences in hsCRP levels also depended on the type of HDP (higher levels in CH and TGH patients in comparison with PC patients). Women with MS had higher hsCRP levels compared with women without MS, and the levels correlated with the number of MS criteria fulfilled. This result suggests that subclinical inflammatory status is correlated with the number of MS components present. Furthermore, hsCRP levels increased with increasing BMIs and waist circumferences.
测量产后妇女高敏 C 反应蛋白（hsCRP）水平，并评估患有各种妊娠高血压疾病（HDP）的女性在产后第 15 周时是否存在代谢综合征（MS）。这是一项在孕 15 周时进行的连续、横断面病例研究。该研究纳入了 264 名就诊于某家妇女医院的女性。这些女性的诊断结果包括一过性妊娠期高血压（TGH=43.2%）、子痫前期（PC=29.5%）、慢性高血压（CH=20.1%）和 PC 合并 CH（7.2%）。CH 组中有 45.8%的女性之前被诊断为高血压。MS 的患病率为 16.7%（CH=42.1%，TGH=13.9%，PC=4.1%，P<0.001）。CH、TGH 和 PC 组的 hsCRP 平均水平分别为 3.79±2.76、3.55±3.15 和 2.89±3.02（P=0.040）。MS 组的 hsCRP 水平更高（4.71±3.15 vs. 3.01±2.88mg·l（-1），P<0.001），且随着 MS 标准满足数量的增加而升高（P<0.001）。hsCRP 水平与体重指数（BMI）（r=0.46）、腰围（r=0.50）或满足的 MS 标准数量（r=0.56）呈正相关。结果表明，hsCRP 水平的差异与 HDP 类型和 MS 的流行程度有关。CH 组的 MS 患病率显著更高，TGH 组处于中间水平，PC 组则显著更低。hsCRP 水平的差异也取决于 HDP 的类型（CH 和 TGH 患者高于 PC 患者）。与无 MS 的女性相比，患有 MS 的女性的 hsCRP 水平更高，且水平与 MS 成分的数量呈正相关。这一结果表明，亚临床炎症状态与 MS 成分的数量有关。此外，hsCRP 水平随着 BMI 和腰围的增加而升高。
