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Therapy: Vitamin B6, B9 and B12 in diabetic nephropathy--beware.

作者信息

Thornalley Paul J, Rabbani Naila

出版信息

Nat Rev Endocrinol. 2010 Sep;6(9):477-8. doi: 10.1038/nrendo.2010.124.

DOI:10.1038/nrendo.2010.124
PMID:20720587
Abstract
摘要

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Therapy: Vitamin B6, B9 and B12 in diabetic nephropathy--beware.治疗：糖尿病肾病中的维生素B6、B9和B12——需谨慎。
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2
Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial.B 族维生素治疗对糖尿病肾病进展的影响：一项随机对照试验。
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3
B-vitamin therapy for diabetic nephropathy.用于治疗糖尿病肾病的B族维生素疗法。
JAMA. 2010 Aug 11;304(6):636; author reply 636-7. doi: 10.1001/jama.2010.1104.
4
B-vitamin therapy for diabetic nephropathy.
JAMA. 2010 Aug 11;304(6):636; author reply 636-7. doi: 10.1001/jama.2010.1105.
5
Effect of Combined Treatment With Folic Acid, Vitamin B, and Vitamin B on Plasma Biomarkers of Inflammation and Endothelial Dysfunction in Women.叶酸、维生素 B 和维生素 B 联合治疗对女性血浆炎症和内皮功能障碍生物标志物的影响。
J Am Heart Assoc. 2018 May 18;7(11):e008517. doi: 10.1161/JAHA.117.008517.
6
[No scientific evidence supports vitamin B treatment of patients with cardiovascular diseases].没有科学证据支持用维生素B治疗心血管疾病患者。
Lakartidningen. 2006;103(45):3464-6.
7
Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRD.关于大剂量叶酸、维生素B12和B6、静脉注射亚叶酸和丝氨酸治疗终末期肾病高同型半胱氨酸血症的对照试验。
J Nephrol. 2003 Jul-Aug;16(4):522-34.
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[Meta-analysis on effect of combined supplementation of folic acid, vitamin B12 and B6 on risk of cardio-cerebrovascular diseases in randomized control trials].[叶酸、维生素B12和B6联合补充对随机对照试验中心脑血管疾病风险影响的Meta分析]
Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Jul;37(7):1028-34. doi: 10.3760/cma.j.issn.0254-6450.2016.07.024.
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Dietary intake of vitamins B6, B12 and folate in relation to homocysteine serum concentration in the adult Polish population - WOBASZ Project.波兰成年人维生素 B6、B12 和叶酸的饮食摄入量与同型半胱氨酸血清浓度的关系-WOBASZ 项目。
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[Homocysteine as a residual risk factor in cardiovascular diseases].[同型半胱氨酸作为心血管疾病的残余风险因素]
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The association between dietary micronutrient patterns and odds of diabetic nephropathy: A case-control study.饮食中微量营养素模式与糖尿病肾病几率之间的关联：一项病例对照研究。
Food Sci Nutr. 2023 Mar 31;11(6):3255-3265. doi: 10.1002/fsn3.3306. eCollection 2023 Jun.
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The Role of Biofactors in Diabetic Microvascular Complications.生物因素在糖尿病微血管并发症中的作用。
Curr Diabetes Rev. 2022;18(4):e250821195830. doi: 10.2174/1871527320666210825112240.
3
Dietary Interventions for Type 2 Diabetes: How Millet Comes to Help.2型糖尿病的饮食干预：小米如何发挥作用。

本文引用的文献

1
Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis.长期血液透析患者短期联合应用甲钴胺和叶酸对血清 ADMA 浓度影响的随机对照试验。
Am J Kidney Dis. 2010 Jun;55(6):1069-78. doi: 10.1053/j.ajkd.2009.12.035. Epub 2010 Apr 28.
2
Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial.B 族维生素治疗对糖尿病肾病进展的影响：一项随机对照试验。
JAMA. 2010 Apr 28;303(16):1603-9. doi: 10.1001/jama.2010.490.
3
Cancer incidence and mortality after treatment with folic acid and vitamin B12.
Front Plant Sci. 2016 Sep 27;7:1454. doi: 10.3389/fpls.2016.01454. eCollection 2016.
4
Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity.代谢组学揭示了脂肪组织中PDXK在脂肪生成和全身胰岛素敏感性中的作用。
Diabetologia. 2016 Apr;59(4):822-32. doi: 10.1007/s00125-016-3863-1. Epub 2016 Feb 2.
5
Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease.糖尿病心血管疾病中针对晚期糖基化终产物（AGEs）的药物治疗方法
Res Cardiovasc Med. 2015 May 23;4(2):e26949. doi: 10.5812/cardiovascmed.4(2)2015.26949. eCollection 2015 May.
6
Amadori glycated proteins: role in production of autoantibodies in diabetes mellitus and effect of inhibitors on non-enzymatic glycation.amadori 糖化蛋白：在糖尿病自身抗体产生中的作用及抑制剂对非酶糖化的影响。
Aging Dis. 2013 Feb;4(1):50-6. Epub 2012 Dec 10.
7
Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes.糖尿病中心肾综合征的近端肾小管细胞假说
Int J Nephrol. 2010 Dec 9;2011:957164. doi: 10.4061/2011/957164.
8
Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics.糖尿病血管并发症的早期和晚期非酶糖基化：治疗方法的探索。
Amino Acids. 2012 Apr;42(4):1193-204. doi: 10.1007/s00726-010-0779-9. Epub 2010 Oct 20.
叶酸和维生素B12治疗后的癌症发病率和死亡率。
JAMA. 2009 Nov 18;302(19):2119-26. doi: 10.1001/jama.2009.1622.
4
High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.大剂量硫胺素治疗2型糖尿病合并微量白蛋白尿患者：一项随机、双盲、安慰剂对照的试点研究。
Diabetologia. 2009 Feb;52(2):208-12. doi: 10.1007/s00125-008-1224-4. Epub 2008 Dec 5.
5
The potential role of thiamine (vitamin B1) in diabetic complications.硫胺素（维生素B1）在糖尿病并发症中的潜在作用。
Curr Diabetes Rev. 2005 Aug;1(3):287-98. doi: 10.2174/157339905774574383.
6
Plasma concentration of asymmetric dimethylarginine (ADMA) predicts cardiovascular morbidity and mortality in type 1 diabetic patients with diabetic nephropathy.1型糖尿病合并糖尿病肾病患者血浆不对称二甲基精氨酸（ADMA）浓度可预测心血管疾病的发病率和死亡率。
Diabetes Care. 2008 Apr;31(4):747-52. doi: 10.2337/dc07-1762. Epub 2007 Dec 27.
7
Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial.降低同型半胱氨酸对晚期慢性肾病和终末期肾病患者死亡率及血管疾病的影响：一项随机对照试验
JAMA. 2007 Sep 12;298(10):1163-70. doi: 10.1001/jama.298.10.1163.
8
Effects of pyridoxamine in combined phase 2 studies of patients with type 1 and type 2 diabetes and overt nephropathy.吡哆胺在1型和2型糖尿病合并显性肾病患者联合2期研究中的作用。
Am J Nephrol. 2007;27(6):605-14. doi: 10.1159/000108104. Epub 2007 Sep 6.
9
Homocysteine lowering with folic acid and B vitamins in vascular disease.在血管疾病中使用叶酸和B族维生素降低同型半胱氨酸水平
N Engl J Med. 2006 Apr 13;354(15):1567-77. doi: 10.1056/NEJMoa060900. Epub 2006 Mar 12.
10
Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells.还原型叶酸载体转运硫胺素单磷酸：硫胺素进入哺乳动物细胞的另一条途径。
Am J Physiol Cell Physiol. 2002 Jun;282(6):C1512-7. doi: 10.1152/ajpcell.00547.2001.