Gydé M C, Randall R F
Ann Otolaryngol Chir Cervicofac. 1978 Jan-Feb;95(1-2):43-55.
A double-blind comparative study of the use of Garamycine (gentamicin) ear drops and TSP (trimethroprim-sulphacetamide-polomyxin B) ear drops in the treatment of 100 cases of otorrhoea due to external otitis, a recurrent otitis media accompanied by perforation of the drum, an infection of the mastoid cavity or a postoperative infection, provided evidence of the effectiveness of both medications. TSP ear drops gave positive results in 42 out of 50 cases treated, whilst for gentamicin aural solution results were positive for 46 out of 50 cases. Gentamicin gave a successful result in 5 of the 8 failures with TSP, whilst TSP cured the four original failures with gentamicin. There were no signs of ototoxicity, of excessive fungal proliferation nor of any local sensitivity to the ear drops. It would seem that these aural preparations are complementary, capable of resulting in the disappearance of the majority of bacterial agents responsible for pathogenic otorrhoea.
一项双盲对比研究，观察庆大霉素耳液和TSP（甲氧苄啶 - 磺胺醋酰 - 多粘菌素B）耳液治疗100例因外耳道炎、伴有鼓膜穿孔的复发性中耳炎、乳突腔感染或术后感染所致耳漏的疗效，结果证明两种药物均有效。TSP耳液治疗的50例中有42例显效，而庆大霉素耳液治疗的50例中有46例显效。庆大霉素使TSP治疗失败的8例中有5例成功，而TSP治愈了庆大霉素治疗最初失败的4例。未出现耳毒性迹象、真菌过度增殖迹象或对耳液的任何局部敏感迹象。看来这些耳用制剂具有互补性，能够使大多数引起致病性耳漏的细菌病原体消失。
