Engert Veronika, Buss Claudia, Khalili-Mahani Najmeh, Wadiwalla Mehereen, Dedovic Katarina, Pruessner Jens C
Douglas Mental Health University Institute, Montreal, Quebec, Canada.
Dev Neuropsychol. 2010;35(5):570-81. doi: 10.1080/87565641.2010.494752.
We explored the associations between early life experience, endocrine regulation, psychological health, and hippocampal integrity in 37 elderly volunteers. Specifically, a neurodevelopmental and psychological mediation model was tested: Retrospective early life parental care was hypothesized to influence hippocampal integrity and the development of self-esteem. In turn, hippocampal volume (via modulation of hypothalamic-pituitary-adrenal axis negative feedback) and self-esteem (via modulation of stress vulnerability) were suggested to influence the cortisol stress response. Results supported the two-mediator model. We propose that early life parental care impacts on an individual's developing brain and personality, which consequently contribute to the shaping of neuroendocrine stress responsivity.
我们在37名老年志愿者中探究了早期生活经历、内分泌调节、心理健康与海马体完整性之间的关联。具体而言，我们测试了一个神经发育和心理中介模型：回顾性的早期生活中父母的照料被假定会影响海马体完整性和自尊的发展。反过来，海马体体积（通过调节下丘脑-垂体-肾上腺轴负反馈）和自尊（通过调节应激易感性）被认为会影响皮质醇应激反应。结果支持了双中介模型。我们提出，早期生活中父母的照料会影响个体发育中的大脑和个性，进而有助于塑造神经内分泌应激反应性。
