Division of General Surgery, Department of Surgery, The Mount Sinai Hospital, New York, New York, USA.
J Surg Oncol. 2010 Nov 1;102(6):704-5. doi: 10.1002/jso.21689.
Glomerulopathy is a rare form of paraneoplastic disease. We present the second reported case of paraneoplastic glomerulopathy due to a retroperitoneal sarcoma. The patient presented with generalized edema and nephrotic syndrome. CT scan showed two large retroperitoneal masses. One large retroperitoneal mass was resected. Post-operatively, she developed kidney failure and biopsy showed minimal change disease. With steroid therapy, patient's symptoms went into remission. We hypothesize that minimal change paraneoplastic glomerulopathy developed due to damage from cytokines released from a T-cell mediated response to the malignancy.
肾小球病是一种罕见的副肿瘤性疾病。我们报告了第二例由腹膜后肉瘤引起的副肿瘤性肾小球病。患者表现为全身性水肿和肾病综合征。CT 扫描显示两个大的腹膜后肿块。一个大的腹膜后肿块被切除。术后，她出现肾衰竭，活检显示微小病变。用类固醇治疗后，患者症状缓解。我们推测微小病变型副肿瘤性肾小球病是由于 T 细胞介导的对恶性肿瘤的反应释放的细胞因子引起的损伤所致。
