Tartaglia Francesco, Blasi Sara, Sgueglia Monica, Polichetti Paolo, Tromba Luciana, Berni Alberto
Department of Surgical Sciences, La Sapienza University, viale Regina Elena 324, 00161 Rome, Italy.
World J Surg Oncol. 2007 Jul 9;5:76. doi: 10.1186/1477-7819-5-76.
Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. Production of Granulocyte-Colony Stimulating Factor, alpha-fetoprotein, paraneoplastic pemphigus and leucocytosis, Acrokeratosis paraneoplastica (Bazex's syndrome) are reported. The present report describes a case of retroperitoneal liposarcoma associated with small plaque parapsoriasis. Our search in the English literature of such a kind of association did not reveal any case reported.
A 74 year male patient was admitted to our hospital because of the presence of an abdominal mass in right iliac fossa. He also complained of a two-year history of psoriasiform eruptions. The CT scan showed a retroperitoneal pelvic mass. Therefore surgical resection of the tumor was performed. After surgery, the skin eruptions disappeared completely in seven days and so a diagnosis of parapsoriasis syndrome was done.
Parallel disappearing of skin eruptions after surgery, typical clinical picture and not specific histology of the cutaneous lesions suggest the diagnosis of small plaque parapsoriasis. Therefore we propose to add Small Plaque Parapsoriasis to the list of paraneoplastic syndromes associated to liposarcoma.
文献报道了与脂肪肉瘤相关的副肿瘤综合征或蛋白质异位产生的极其罕见的病例。有粒细胞集落刺激因子、甲胎蛋白、副肿瘤性天疱疮和白细胞增多症、副肿瘤性肢端角化病（巴泽克斯综合征）的产生的报道。本报告描述了一例与小斑块状副银屑病相关的腹膜后脂肪肉瘤病例。我们对英文文献中此类关联的检索未发现任何报道病例。
一名74岁男性患者因右髂窝出现腹部肿块入院。他还主诉有两年的银屑病样皮疹病史。CT扫描显示腹膜后盆腔肿块。因此对肿瘤进行了手术切除。术后，皮肤皮疹在七天内完全消失，因此做出了副银屑病综合征的诊断。
术后皮肤皮疹同时消失、典型的临床表现以及皮肤病变不具有特异性组织学特征提示小斑块状副银屑病的诊断。因此，我们建议将小斑块状副银屑病添加到与脂肪肉瘤相关的副肿瘤综合征列表中。
