Weston Area Health Trust, Weston General Hospital, Weston-super-Mare, Somerset, UK.
Diabet Med. 2010 Sep;27(9):1080-3. doi: 10.1111/j.1464-5491.2010.03036.x.
To rapidly reduce serum triglyceride to a safe serum level. Severe hypertriglyceridaemia is associated with uncontrolled diabetes, obesity and poor physical activity. Even moderate increases in triglyceride levels (> 5mmol/L) confer an increased risk of pancreatitis and coronary artery disease. We present two patients with diabetes and serum triglyceride levels of greater than 85mmol/L despite polypharmacy intervention.
72-hour intravenous insulin infusion was administered.
Serum triglyceride levels fell to 9.4 and 4.6 mmol/L respectively, without adverse events and sustained effect over several months.
We suggest the use of intravenous insulin infusion where lifestyle and oral drug therapies have failed can impact on severe hypertriglyceridaemia.
迅速将血清甘油三酯降低到安全水平。严重的高甘油三酯血症与未控制的糖尿病、肥胖和缺乏体育活动有关。即使甘油三酯水平中度升高（>5mmol/L），也会增加胰腺炎和冠心病的风险。我们报告了 2 例糖尿病患者，尽管采用了多种药物治疗，但血清甘油三酯水平仍大于 85mmol/L。
给予 72 小时静脉内胰岛素输注。
血清甘油三酯水平分别降至 9.4 和 4.6mmol/L，无不良反应，且在数月内持续有效。
我们建议在生活方式和口服药物治疗失败的情况下使用静脉内胰岛素输注，可以有效控制严重高甘油三酯血症。
