抗 NMDAR 脑炎患者的脑免疫组织病理学研究。
Brain immunohistopathological study in a patient with anti-NMDAR encephalitis.
机构信息
Service de Neurologie, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
出版信息
Eur J Neurol. 2011 Jun;18(6):929-31. doi: 10.1111/j.1468-1331.2010.03180.x. Epub 2010 Aug 16.
BACKGROUND AND PURPOSE
Anti-N-methyl-D-asparate (NMDA) receptor encephalitis is thought to be antibody-mediated. To perform an immunohistopathological study of the inflammatory reaction in a brain biopsy performed before immunomodulatory treatments in a patient with anti-NMDA receptor encephalitis.
METHODS
An immunohistochemical study was performed using CD3, CD68, CD20, CD138 and CD1a antibodies.
RESULTS
Prominent B-cell cuffing was present around brain vessels accompanied by some plasma cells, while macrophages and T cells were scattered throughout the brain parenchyma.
CONCLUSION
These findings suggest that the B cells interact with the T cells and are involved in antibody secretion by the plasma cells.
背景与目的
抗 N-甲基-D-天冬氨酸（NMDA）受体脑炎被认为是抗体介导的。对一名抗 NMDA 受体脑炎患者在免疫调节治疗前进行的脑活检中的炎症反应进行免疫组织病理学研究。
方法
使用 CD3、CD68、CD20、CD138 和 CD1a 抗体进行免疫组织化学研究。
结果
在脑血管周围有明显的 B 细胞包绕，伴有一些浆细胞，而巨噬细胞和 T 细胞则散布在脑实质中。
结论
这些发现表明 B 细胞与 T 细胞相互作用，并参与浆细胞的抗体分泌。
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