在 MM1 型散发性克雅氏病的日本病例中，存活至无动性缄默状态的情况与高加索人相似。
Survival to akinetic mutism state in Japanese cases of MM1-type sporadic Creutzfeldt-Jakob disease is similar to Caucasians.
机构信息
Department of Neurology, Oyamada Memorial Spa Hospital, Yokkaichi, Japan.
出版信息
Eur J Neurol. 2011 Jul;18(7):999-1002. doi: 10.1111/j.1468-1331.2010.03185.x. Epub 2010 Aug 16.
BACKGROUND
It is not known whether the clinical course of Japanese sporadic Creutzfeldt-Jakob disease (sCJD) cases differs from that of Caucasian sCJD cases.
PATIENTS AND METHODS
To investigate the clinical course of Japanese sCJD, clinical findings from 29 patients with Japanese MM1-type sCJD were retrospectively evaluated and compared to Caucasian sCJD findings.
RESULTS
Survival of Japanese MM1-type sCJD up to the time of akinetic mutism state is similar to that of Caucasian subjects. However, the total disease duration of Japanese patients was approximately three times longer.
CONCLUSIONS
The present observations indicate that Japanese sCJD cases generally show a longer disease duration because of the longer survival period after reaching the akinetic mutism state.
背景
日本散发性 Creutzfeldt-Jakob 病（sCJD）病例的临床病程是否与高加索 sCJD 病例不同尚不清楚。
患者和方法
为了研究日本 sCJD 的临床过程，回顾性评估了 29 例日本 MM1 型 sCJD 患者的临床发现，并与高加索 sCJD 发现进行了比较。
结果
日本 MM1 型 sCJD 患者到达无动性缄默状态的存活时间与高加索人群相似。然而，日本患者的总病程大约长三倍。
结论
目前的观察结果表明，由于进入无动性缄默状态后的存活期延长，日本 sCJD 病例通常表现出更长的疾病持续时间。
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