Pharmacology and Toxicology Division, Defence Research and Development Establishment (DRDE), Jhansi Road Gwalior, MP, India.
J Pharm Pharmacol. 2010 Jan;62(1):115-23. doi: 10.1211/jpp.62.01.0013.
Persistent hyperglycaemia results in oxidative stress along with the generation of oxygen free radicals and appears to be an important factor in the production of secondary complications in diabetes. The aim of this work was to evaluate markers of oxidative stress in heart tissue along with the protective, antioxidant and antidiabetic activity of 30%Aloe vera gel in diabetic rats.
Streptozocin was given as a single intravenous injection and 30%Aloe vera gel was given in two doses for 20 days, orally. Blood glucose, glycosylated haemoglobin, blood reduced glutathione, serum lactate dehydrogenase and serum creatine kinase levels were measured on day 21 after drug treatment. Heart rate and mean blood pressure were recorded at the end of the study. Different biochemical variables were evaluated in the heart tissue, including thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase and catalase in diabetic and in Aloe vera-treated diabetic rats.
In streptozocin diabetic rats, the TBARS level was increased significantly, superoxide dismutase and reduced glutathione significantly decreased, and the catalase level was significantly increased. Aloe vera 30% gel (200 mg/kg) treatment in diabetic rats reduced the increased TBARS and maintained the superoxide dismutase and catalase activity up to the normal level. Aloe vera gel increased reduced glutathione by four times in diabetic rats.
Aloe vera gel at 200 mg/kg had significant antidiabetic and cardioprotective activity.
持续高血糖会导致氧化应激，产生氧自由基，这似乎是糖尿病继发并发症产生的一个重要因素。本研究旨在评估氧化应激标志物在心肌组织中的变化，并研究 30%库拉索芦荟凝胶对糖尿病大鼠的抗氧化、保护和抗糖尿病作用。
链脲佐菌素一次性静脉注射，连续 20 天每天两次给予 30%库拉索芦荟凝胶灌胃。药物治疗后第 21 天测定血糖、糖化血红蛋白、血还原型谷胱甘肽、血清乳酸脱氢酶和血清肌酸激酶水平。研究结束时记录心率和平均血压。评估糖尿病和经库拉索芦荟治疗的糖尿病大鼠心脏组织中的不同生化变量，包括丙二醛（TBARS）、还原型谷胱甘肽、超氧化物歧化酶和过氧化氢酶。
链脲佐菌素诱导的糖尿病大鼠 TBARS 水平显著升高，超氧化物歧化酶和还原型谷胱甘肽显著降低，过氧化氢酶水平显著升高。糖尿病大鼠给予 30%库拉索芦荟凝胶（200mg/kg）治疗可降低升高的 TBARS，使超氧化物歧化酶和过氧化氢酶活性恢复至正常水平。库拉索芦荟凝胶使糖尿病大鼠的还原型谷胱甘肽增加了 4 倍。
200mg/kg 库拉索芦荟凝胶具有显著的抗糖尿病和心脏保护作用。
