National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Regul Toxicol Pharmacol. 2010 Nov;58(2):167-9; discussion 170-2. doi: 10.1016/j.yrtph.2010.08.011. Epub 2010 Aug 17.
Ethylbenzene has been evaluated for carcinogenic activity in Fischer rats and B6C3F1 mice exposed by inhalation (Chan et al., 1998; Chan, 1999) and in Sprague-Dawley rats after oral exposure (Maltoni et al., 1985,1997). Bioassay findings are summarized below to expand on those not stated clearly or completely in Saghir et al. (2010). Overall in these three studies animals exposed to ethylbenzene had increased tumors in rats for kidneys, testes, head (including rare neuroesthesioepitheliomas), and total malignant tumors, whilst in mice tumor incidences were increased in the lung and liver (Huff, 2002). Thus ethylbenzene was carcinogenic by two exposure routes to both sexes of two species of rodents, two strains of rats, and one strain of mice, causing collectively tumors in five different target organs and a composite of "total malignant" tumors.
苯乙烯在 Fischer 大鼠和 B6C3F1 小鼠经吸入途径（Chan 等人，1998 年；Chan，1999 年）以及 Sprague-Dawley 大鼠经口服暴露（Maltoni 等人，1985 年，1997 年）的情况下进行了致癌性评估。下文总结了生物测定结果，对 Saghir 等人（2010 年）未明确或完整说明的内容进行了扩展。总的来说，在这三项研究中，接触苯乙烯的动物在肾脏、睾丸、头部（包括罕见的神经外胚层瘤）和总恶性肿瘤方面，雄性和雌性两种啮齿动物、两种大鼠品系和一种小鼠品系的肿瘤发生率均有所增加，而在小鼠中，肺部和肝脏的肿瘤发生率增加（Huff，2002 年）。因此，苯乙烯通过两种暴露途径对两种啮齿动物的雌雄两性、两种大鼠品系和一种小鼠品系具有致癌性，导致五种不同靶器官的肿瘤和“总恶性”肿瘤的综合发生。
