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医疗保健和老年护理机构中化学物质慢性吸入的定量健康风险评估

Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities.

作者信息

Colas Anaïs, Baudet Alexandre, Le Cann Pierre, Blanchard Olivier, Gangneux Jean-Pierre, Baurès Estelle, Florentin Arnaud

机构信息

Faculté de Médecine, Université de Lorraine, F-54505 Vandoeuvre-les-Nancy, France.

CHRU-Nancy, F-54505 Vandoeuvre-les-Nancy, France.

出版信息

Toxics. 2022 Mar 15;10(3):141. doi: 10.3390/toxics10030141.

Abstract

Previous studies have described the chemical pollution in indoor air of healthcare and care facilities. From these studies, the main objective of this work was to conduct a quantitative health risk assessment of the chronic inhalation of chemical compounds by workers in healthcare and elderly care facilities (hospitals, dental and general practitioner offices, pharmacies and nursing homes). The molecules of interest were 36 volatile and 13 semi-volatile organic compounds. Several professional exposure scenarios were developed in these facilities. The likelihood and severity of side effects that could occur were assessed by calculating the hazard quotient for deterministic effects, and the excess lifetime cancer risk for stochastic effects. No hazard quotient was greater than 1. Three compounds had a hazard quotient above 0.1: 2-ethyl-1-hexanol in dental and general practitioner offices, ethylbenzene and acetone in dental offices. Only formaldehyde presented an excess lifetime cancer risk greater than 1 × 10 in dental and general practitioner offices (maximum value of 3.8 × 10 for general practitioners). The health risk for chronic inhalation of most compounds investigated did not appear to be of concern. Some values tend to approach the acceptability thresholds justifying a reflection on the implementation of corrective actions such as the installation of ventilation systems.

摘要

先前的研究已经描述了医疗保健和护理机构室内空气中的化学污染情况。基于这些研究,本工作的主要目标是对医疗保健和老年护理机构(医院、牙科和全科医生诊所、药房和养老院)的工作人员长期吸入化学化合物进行定量健康风险评估。所关注的分子为36种挥发性有机化合物和13种半挥发性有机化合物。在这些机构中制定了几种职业接触情景。通过计算确定性效应的危害商和随机效应的终生超额癌症风险,评估了可能发生的副作用的可能性和严重程度。没有危害商大于1的情况。有三种化合物的危害商高于0.1:牙科和全科医生诊所中的2-乙基-1-己醇、牙科诊所中的乙苯和丙酮。只有甲醛在牙科和全科医生诊所中的终生超额癌症风险大于1×10(全科医生的最大值为3.8×10)。对大多数所研究化合物的长期吸入健康风险似乎无需担忧。一些数值趋于接近可接受阈值,这表明有必要考虑采取诸如安装通风系统等纠正措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e02/8954219/a9a11447fda8/toxics-10-00141-g001.jpg

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