Fagard R, Staessen J, Amery A
Department of Pathophysiology, Faculty of Medicine, University of Leuven, Belgium.
J Hum Hypertens. 1991 Apr;5(2):69-75.
To study whether exercise blood pressure is more closely related to the complications of hypertension than resting blood pressure, 169 patients with essential hypertension, aged 16-66 years, (WHO stages I and II), underwent a graded uninterrupted exercise test on the bicycle ergometer up to exhaustion. BP was measured in intra-arterially. Target organ damage was assessed by eye-fundus grade and by electrocardiographic voltage criteria and T-wave patterns. After adjustment for relevant covariates (age, gender, body height and weight), the manifestations of target organ damage were significantly related to systolic (r ranging from 0.19 to 0.39) and diastolic (r ranging from 0.11 to 0.30) intra-arterial pressure at supine rest. The complications of hypertension were not more closely related to BP during upright submaximal and peak exercise than to resting BP, and exercise BP did not contribute independently from BP at rest to their variance. In conclusion, exercise BP is not better related to target organ damage than BP at rest in patients with essential hypertension.
为研究运动血压是否比静息血压与高血压并发症的关系更为密切，169例年龄在16 - 66岁的原发性高血压患者（WHO分级为I级和II级），在自行车测力计上进行了分级不间断运动试验直至力竭。通过动脉内测量血压。通过眼底分级以及心电图电压标准和T波形态评估靶器官损害。在对相关协变量（年龄、性别、身高和体重）进行校正后，靶器官损害的表现与仰卧位静息时的收缩压（r范围为0.19至0.39）和舒张压（r范围为0.11至0.30）显著相关。高血压并发症与直立次最大运动和峰值运动期间的血压相比，与静息血压的关系并不更密切，并且运动血压对其变异性的影响并非独立于静息血压。总之，在原发性高血压患者中，运动血压与靶器官损害的关系并不优于静息血压。
