人群中 37 种人乳头瘤病毒型别抗体的流行率和稳定性——基于人群的纵向研究。

Prevalence and stability of antibodies to 37 human papillomavirus types--a population-based longitudinal study.

机构信息

Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, The University of Queensland, Brisbane, Queensland, Australia.

出版信息

Virology. 2010 Nov 10;407(1):26-32. doi: 10.1016/j.virol.2010.07.046. Epub 2010 Aug 17.

DOI:10.1016/j.virol.2010.07.046

PMID:20723959

Abstract

Information about serostability of cutaneous HPV types over time is very limited. We investigated seroprevalence and serostability of 37 different HPV types over 4½ years in an Australian population-based study. Sera and data were analyzed for 390 people who had never been diagnosed with SCC and had blood collected in 1992, 1993 and 1996. Eighty-six percent of participants were seropositive to at least one of the 37 HPV types at baseline. HPV-4 was the type with the highest seroprevalence (41%), followed by HPV-38 and HPV-8 (both 33%). Over 90% of people retained their baseline serostatus during the 4½ year follow-up. Highest serostability was observed for HPV-88 (99.7% stayed seropositive or seronegative), while HPV-65 was least stable with 17% altering their serostatus during follow-up. Seroprevalence to cutaneous HPV types are relatively stable over time, and a single measure can be used as a reasonable marker of long-term antibody status.

摘要

有关皮肤 HPV 型别随时间的血清稳定性的信息非常有限。我们在一项澳大利亚人群为基础的研究中，调查了 37 种不同 HPV 型别在 4 年半时间内的血清阳性率和血清稳定性。对从未被诊断患有 SCC 且在 1992 年、1993 年和 1996 年采集了血液的 390 人进行了血清学和数据分析。86%的参与者在基线时至少对 37 种 HPV 型别中的一种呈血清阳性。HPV-4 的血清阳性率最高（41%），其次是 HPV-38 和 HPV-8（均为 33%）。在 4 年半的随访期间，超过 90%的人保持了基线的血清状态。HPV-88 的血清稳定性最高（99.7%的人保持血清阳性或阴性），而 HPV-65 的血清稳定性最低，在随访期间有 17%的人改变了血清状态。皮肤 HPV 型别的血清阳性率随时间相对稳定，单次检测可作为长期抗体状态的合理标志物。