N,O-二酰基-4-苯甲酰基-N-苯基亚硝胺作为光诱导的 DNA 断裂剂。
N,O-diacyl-4-benzoyl-N-phenylhydroxylamines as photoinduced DNA cleaving agents.
机构信息
Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India.
出版信息
Bioorg Med Chem Lett. 2010 Sep 15;20(18):5414-7. doi: 10.1016/j.bmcl.2010.07.116. Epub 2010 Aug 1.
PMID:20724149
Abstract
Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.
摘要
使用 310nm 的紫外光照射 10 分钟，可诱导 N,O-二酰基-4-苯甲酰基-N-苯基亚氨基醇在氮氧键处发生光诱导均裂，生成酰氨基和过氧自由基，导致 DNA 在 pH7.0 时发生单链断裂。此外，N,O-二酰基-4-苯甲酰基-N-苯基亚氨基醇的 DNA 切割能力既与其浓度有关，也与其酰基取代基有关。
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