Ponnapakkam Tulasi, Bradford Elease, Gensure Robert
Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
Clin Pediatr (Phila). 2010 Nov;49(11):1053-60. doi: 10.1177/0009922810376320. Epub 2010 Aug 19.
This study was conducted to determine if vitamin D supplementation is required to prevent rickets in breast-fed infants. Breast-feeding rates are increasing, and there are concerns about whether the vitamin D content of breast milk is sufficient. There are a few treatment trials of vitamin D supplementation in breast-fed infants; these were conducted in northern climates. The authors therefore performed a prospective clinical trial comparing vitamin D supplementation with placebo as control in southern Louisiana. Blood samples and questionnaires were collected at birth, 2, 4, and 6 months of age. There were no cases of rickets observed, and no differences in alkaline phosphatase levels between groups. Thus, there was no evidence that vitamin D supplementation reduced rickets risk in the authors' study population. This suggests that the current recommendations for universal vitamin D supplementation of breast-fed infants throughout the United States may need to be revised.
本研究旨在确定母乳喂养的婴儿是否需要补充维生素D以预防佝偻病。母乳喂养率正在上升，人们担心母乳中的维生素D含量是否充足。在母乳喂养的婴儿中进行了一些维生素D补充剂的治疗试验；这些试验是在北方气候条件下进行的。因此，作者在路易斯安那州南部进行了一项前瞻性临床试验，将维生素D补充剂与安慰剂作为对照进行比较。在出生时、2个月、4个月和6个月时采集血样和问卷。未观察到佝偻病病例，两组之间碱性磷酸酶水平也无差异。因此，在作者的研究人群中，没有证据表明补充维生素D可降低佝偻病风险。这表明，目前美国关于普遍为母乳喂养婴儿补充维生素D的建议可能需要修订。
