Dawodu Adekunle, Agarwal Mukesh, Hossain Moshaddeque, Kochiyil Jose, Zayed Reem
Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, United Arab Emirates.
J Pediatr. 2003 Feb;142(2):169-73. doi: 10.1067/mpd.2003.63.
OBJECTIVE: To determine the prevalence of hypovitaminosis D in exclusively breast-feeding infants and their mothers in a community where maternal sunshine exposure is low. STUDY DESIGN: Serum levels of calcium, phosphate, alkaline phosphatase, 25-hydroxy vitamin D (25-OHD), and intact parathyroid hormone were measured in 90 unsupplemented healthy term breast-feeding Arab/South Asian infants and their mothers in summer. Maternal dietary vitamin D intake was also estimated. RESULTS: The median age of infants was 6 weeks. The median serum 25-OHD concentrations in mothers (8.6 ng/mL) and infants (4.6 ng/mL) were low, and 61% of the mothers and 82% of the 78 infants tested had hypovitaminosis D (serum 25-OHD <10 ng/mL). The infants with hypovitaminosis D had elevated serum alkaline phosphatase and a tendency to higher serum intact parathyroid hormone levels. The average daily maternal vitamin D intake from commercial milk was 88 IU. CONCLUSIONS: Hypovitaminosis D is common in summer in exclusively breast-feeding infants and their mothers. The results provide justification for vitamin D supplementation of breast-feeding infants and mothers in the United Arab Emirates. Low vitamin D intake probably contributed to low maternal vitamin D status.
目的:在一个母亲日照较少的社区,确定纯母乳喂养婴儿及其母亲维生素D缺乏症的患病率。 研究设计:在夏季,对90名未补充维生素D的健康足月纯母乳喂养的阿拉伯/南亚婴儿及其母亲测量血清钙、磷、碱性磷酸酶、25-羟基维生素D(25-OHD)和完整甲状旁腺激素水平。同时估算母亲膳食中维生素D的摄入量。 结果:婴儿的中位年龄为6周。母亲(8.6 ng/mL)和婴儿(4.6 ng/mL)血清25-OHD浓度中位数较低,61%的母亲和接受检测的78名婴儿中的82%患有维生素D缺乏症(血清25-OHD<10 ng/mL)。患有维生素D缺乏症的婴儿血清碱性磷酸酶升高,血清完整甲状旁腺激素水平有升高趋势。母亲从商业牛奶中每日摄入维生素D的平均量为88 IU。 结论:纯母乳喂养婴儿及其母亲在夏季维生素D缺乏症很常见。研究结果为阿拉伯联合酋长国的母乳喂养婴儿和母亲补充维生素D提供了依据。维生素D摄入量低可能导致母亲维生素D水平低下。
Indian Pediatr. 2007-12
Ann Trop Paediatr. 2001-3
Turk J Pediatr. 2003
Indian Pediatr. 2006-3
J Pediatr Gastroenterol Nutr. 2011-7
World J Clin Pediatr. 2024-3-9
Cochrane Database Syst Rev. 2020-12-11