Neonatal Intensive Care Unit, University Hospital of Ioannina, University of Ioannina, Ioannina, Greece.
Diabetes Care. 2010 Nov;33(11):2468-70. doi: 10.2337/dc10-1190. Epub 2010 Aug 19.
To evaluate metabolic syndrome and cardiovascular disease risk factors in prepubertal children born large for gestational age (LGA) to nondiabetic, nonobese mothers.
At 6-7 years of age, the comparison of various factors was made between 31 LGA and 34 appropriate-for-gestational-age (AGA) children: fibrinogen, antithrombin III, protein C and S, fasting insulin, glucose, homeostasis assessment model of insulin resistance (HOMA-IR) index, adiponectin, leptin, visfatin, IGF-1, IGF-binding protein (IGFBP)-1, IGFBP-3, lipids, and the genetic factors V Leiden G1691A mutation, prothrombin 20210A/G polymorphism, and mutation in the enzyme 5,10-methylenetetrahydrofolate-reductase gene (MTHFR-C677T).
LGA children had higher levels of leptin (P<0.01), fasting insulin (P<0.01), and HOMA-IR (P<0.01), but lower IGFBP-3 (P=0.0001), fibrinogen (P=0.0001), and lipoprotein(a) (P<0.001) than AGA children. Significantly more LGA children were homozygous for the MTHFR-C677T mutation (P=0.0016).
Being born LGA to nondiabetic, nonobese mothers is associated with diverse effects on cardiometabolic risk factors at prepuberty.
评估非糖尿病、非肥胖母亲所生的巨大儿（LGA）在青春期前儿童中的代谢综合征和心血管疾病风险因素。
在 6-7 岁时，将 31 名 LGA 儿童和 34 名适当胎龄（AGA）儿童的各种因素进行比较：纤维蛋白原、抗凝血酶 III、蛋白 C 和 S、空腹胰岛素、血糖、胰岛素抵抗稳态模型评估（HOMA-IR）指数、脂联素、瘦素、内脏脂肪素、IGF-1、IGF 结合蛋白（IGFBP）-1、IGFBP-3、脂质以及 V Leiden G1691A 突变、凝血酶原 20210A/G 多态性和酶 5,10-亚甲基四氢叶酸还原酶基因（MTHFR-C677T）突变等遗传因素。
LGA 儿童的瘦素（P<0.01）、空腹胰岛素（P<0.01）和 HOMA-IR（P<0.01）水平较高，但 IGFBP-3（P=0.0001）、纤维蛋白原（P=0.0001）和脂蛋白（a）（P<0.001）水平较低。LGA 儿童中 MTHFR-C677T 突变的纯合子明显更多（P=0.0016）。
非糖尿病、非肥胖母亲所生的巨大儿在青春期前就与多种心血管代谢风险因素有关。
