Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba, Japan.
Plant Signal Behav. 2010 Aug;5(8):1045-7. doi: 10.4161/psb.5.8.12407. Epub 2010 Aug 1.
Cytosolic free Ca(2+) mobilization induced by microbe/pathogen-associated molecular patterns (MAMPs/PAMPs) play key roles in plant innate immunity. However, components involved in Ca(2+) signaling pathways still remain to be identified and possible involvement of the CBL (calcineurin B-like proteins)-CIPK (CBL-interacting protein kinases) system in biotic defense signaling has yet to be clarified. Recently we identified two CIPKs, OsCIPK14 and OsCIPK15, which are rapidly induced by MAMPs, involved in various MAMP-induced immune responses including defense-related gene expression, phytoalexin biosynthesis and hypersensitive cell death. MAMP-induced production of reactive oxygen species as well as cell browning were also suppressed in OsCIPK14/15-RNAi transgenic cell lines. Possible molecular mechanisms and physiological functions of the CIPKs in plant innate immunity are discussed.
胞质游离 Ca(2+)动员由微生物/病原体相关分子模式 (MAMPs/PAMPs) 诱导，在植物先天免疫中发挥关键作用。然而，Ca(2+)信号通路涉及的成分仍有待确定，CBL (钙调神经磷酸酶 B 样蛋白)-CIPK (CBL 相互作用蛋白激酶)系统在生物防御信号中的可能参与尚不清楚。最近我们鉴定了两个 CIPKs，OsCIPK14 和 OsCIPK15，它们被 MAMPs 快速诱导，参与多种 MAMP 诱导的免疫反应，包括防御相关基因表达、植保素生物合成和过敏性细胞死亡。在 OsCIPK14/15-RNAi 转基因细胞系中，MAMP 诱导的活性氧产生和细胞褐变也受到抑制。讨论了 CIPKs 在植物先天免疫中的可能分子机制和生理功能。
