Department of Pediatrics and Immunology, University of Washington, Seattle Children's Research Institute, Seattle, WA, USA.
Cell Cycle. 2010 Sep 1;9(17):3565-74. doi: 10.4161/cc.9.17.12798. Epub 2010 Sep 25.
A unique property of lymphocytes among all body tissues is their capacity for rapid proliferation in the context of responding to infectious challenges. Lymphocyte proliferation involves a transition from a quiescent metabolic state adjusted to maintain cellular energy homeostasis, to a proliferative metabolic state in which aerobic glycolysis is used to generate energy and biosynthetic precursors necessary for the accumulation of cell mass. Here we show that modulation of TRPM7 channel function in tumor B-lymphocytes directly induces quiescent/proliferative metabolic transitions. As TRPM7 is widely expressed outside of the immune system, our results suggest that TRPM7 may play an active role in regulating metabolic transitions associated with rapid cellular proliferation and malignancy.
淋巴细胞在所有身体组织中具有独特的属性，即它们能够在应对感染性挑战的情况下迅速增殖。淋巴细胞增殖涉及从适应维持细胞能量稳态的静止代谢状态向有氧糖酵解用于产生能量和生物合成前体以积累细胞质量的增殖代谢状态的转变。在这里，我们表明，肿瘤 B 淋巴细胞中 TRPM7 通道功能的调节可直接诱导静止/增殖代谢转变。由于 TRPM7 在免疫系统之外广泛表达，我们的结果表明，TRPM7 可能在调节与快速细胞增殖和恶性肿瘤相关的代谢转变中发挥积极作用。
