Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA.
Crit Care Med. 2010 Sep;38(9 Suppl):S460-8. doi: 10.1097/CCM.0b013e3181ec667f.
Necrotizing soft tissue infection is a severe illness that is associated with significant morbidity and mortality. It is often caused by a wide spectrum of pathogens and is most frequently polymicrobial. Care for patients with necrotizing soft tissue infection requires a team approach with expertise from critical care, surgery, reconstructive surgery, and rehabilitation specialists. The early diagnosis of necrotizing soft tissue infection is challenging, but the keys to successful management of patients with necrotizing soft tissue infection are early recognition and complete surgical debridement. Early initiation of appropriate broad-spectrum antibiotic therapy must take into consideration the potential pathogens. Critical care management components such as the initial fluid resuscitation, end-organ support, pain management, nutrition support, and wound care are all important aspects of the care of patients with necrotizing soft tissue infection. Soft tissue reconstruction should take into account both functional and cosmetic outcome.
坏死性软组织感染是一种严重的疾病，与较高的发病率和死亡率相关。它通常由广泛的病原体引起，且最常为多种微生物混合感染。治疗坏死性软组织感染的患者需要多学科团队协作，涉及重症监护、外科、重建外科和康复专家。坏死性软组织感染的早期诊断具有挑战性，但成功管理坏死性软组织感染患者的关键是早期识别和彻底的外科清创。早期开始适当的广谱抗生素治疗必须考虑潜在的病原体。重症监护管理组件，如初始液体复苏、终末器官支持、疼痛管理、营养支持和伤口护理，都是坏死性软组织感染患者护理的重要方面。软组织重建应考虑功能和美容效果。
