Bolevich S B, Stupin V A, Gakhramanov T V, Khokonov M A, Silina E V, Men'shova N I, Bogdanova L S
Khirurgiia (Mosk). 2010(7):65-70.
The main objective of a research in the early diagnostics of a functional condition of a liver, is to estimate the degree of the level of its expressiveness and timely pathogenetic correction on the basis of the free radical system processes of studying of patients with mechanical jaundice. Results were carried out among 61 patients with pathologies of bile tracts( biliary ducts) which proved the essential role of free radical processes with strengthening of peroxidation of membrane lipids against the absolute or relative insufficiency of endogenic antioxidants in the mechanism of development of hepatic insufficiency at the given category of patients with the highest degree expressed at the serious conditions of the patients with malignant diseases. It is revealed that the inclusion of energy corrector antioxidants of reamberin to the therapy as a part of standard schemes of treatment promoted positive regressing dynamics of parameters of free radical processes that are correlated with positive clinical symptoms and outcome of diseases.
肝脏功能状态早期诊断研究的主要目的，是在对机械性黄疸患者自由基系统过程进行研究的基础上，评估其表达水平的程度以及及时进行病因学纠正。对61例胆管（胆道）疾病患者进行了相关研究，结果证明自由基过程在膜脂质过氧化增强方面具有重要作用，这是由于内源性抗氧化剂绝对或相对不足，在这类患者肝衰竭发生机制中所致，在恶性疾病患者的严重病情中表现最为明显。研究发现，在治疗标准方案中加入能量校正抗氧化剂雷美替胺，可促进与疾病积极临床症状和转归相关的自由基过程参数呈现正向回归动态变化。
